Research Progress in the Convalescent Plasma Therapy of Virus Infection

doi:10.3969/j.issn.1671-2587.2020.04.001

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2020, Vol. 22 ›› Issue (4): 337-342.DOI: 10.3969/j.issn.1671-2587.2020.04.001

Research Progress in the Convalescent Plasma Therapy of Virus Infection

ZHU Xin-fang, WANG Yuan, DU Dan-xin, et al.

Department of Blood Transfusion, Huashan Hospital, Fudan University, Shanghai 200040

Received:2020-04-20 Online:2020-08-20 Published:2020-08-12

Abstract

Abstract: Convalescent plasma (CP) has been applied to the treatment of many virus infectious diseases. This paper summarized the previous researches in contagious viral diseases treated with CP, and analyzed CP therapy as a potential treatment for COVID-19. We summarized the technical progress of CP in recruitment, plasma treatment, antibody titer detection, and its clinical treatment experiences in avian influenza virus, MERS-CoV, SARS-CoV, EBOV, SARS-CoV-2 and other viral infections, and adverse events related to plasma transfusion. Some case reports on CP therapies and retrospective analysis suggest that CP can reduce case fatality rate (CFR), so it can be used as a potential treatment for COVID-19.

Key words: Coronavirus, disease, 19, Convalescent, plasma, Randomized, controlled, trial

CLC Number:

R457

ZHU Xin-fang, WANG Yuan, DU Dan-xin, et al.. Research Progress in the Convalescent Plasma Therapy of Virus Infection[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2020, 22(4): 337-342.

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Research Progress in the Convalescent Plasma Therapy of Virus Infection

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