• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)
临床输血与检验

临床输血与检验 ›› 2016, Vol. 18 ›› Issue (1): 39-43.DOI: 10.3969/j.issn.1671-2587.2016.01.013

• 临床检验研究 • 上一篇    下一篇

血清3种肿瘤标志物检测在卵巢肿瘤诊断与临床分期中的应用

孙业富,张志锋,夏爱萍,陈桂明   

  1. 225009 江苏省扬州市职业大学医学院（孙业富,张志锋）; 苏州大学附属高邮市人民医院（夏爱萍,陈桂明）
  • 收稿日期:2015-07-15 出版日期:2016-02-20 发布日期:2016-10-10
  • 作者简介:孙业富(1973-),男,江苏扬州人,副教授,主要从事肿瘤免疫检测和血液学研究,（Tel）15062874628（E-mail）syfgy@sina.com。

Detection of Three Tumor Markers in Diagnosis and Clinical Staging of Ovarian Neoplasm

SUN Ye-fu, ZHANG Zhi-feng, XIA Ai-ping, et al   

  1. Medical Center of Yangzhou Polytechnic University,Jiangsu, Yangzhou 225009
  • Received:2015-07-15 Online:2016-02-20 Published:2016-10-10

PDF

862

摘要： 目的研究和评价HE4、CA125和PDGF-BB三种血清肿瘤标志物在恶性卵巢肿瘤诊断、临床分期和治疗中的应用价值。方法选择2012年6月22日~2014年10月28日扬州市苏北人民医院、扬州市第一人民医院收治的卵巢包块患者216例（均行手术等治疗）,其中未绝经组恶性卵巢肿瘤26例、良性卵巢肿瘤53例及60例健康女性（对照组）;绝经组恶性卵巢肿瘤50例、良性卵巢肿瘤87例及108例健康女性（对照组）。同期选择在该院体检中心经体检合格的健康女性168例作为对照组,利用免疫化学发光法和ELISA法检测未绝经组和绝经组中患者血清HE4、CA125和PDGF-BB含量,并对比分析三者在恶性卵巢肿瘤的诊断和临床分期中的应用价值。结果恶性卵巢肿瘤患者（包括未绝经组和绝经组）的HE4、CA125和PDGF-BB血清水平均明显高于正常对照组和良性卵巢肿瘤（P均<0.01）。Spearman相关分析显示相关性具有统计学意义,且HE4的相关性最高（r=0.613)。HE4和CA125的敏感度优于PDGF-BB,差异有统计学意义（均P<0.05）,但HE4和CA125两者相比较差异无统计学意义（P>0.05）。同时HE4的特异度、准确度都是最优的,差异有统计学意义（均P<0.05）。当HE4临界值在未绝经组为36.5 pmol/L时,特异度为88.1%、准确度为87.1%;在绝经组为56.8pmol/L时,特异度为93.5%、准确度为88.7%。结论检测血清HE4、CA125和PDGF-BB肿瘤标志物水平变化,对于了解病情、观察疗效和预后判断均具有实用价值。

关键词: 卵巢肿瘤, 肿瘤标志物, 人附睾上皮分泌蛋白4, 血小板源性生长因子

Abstract: ObjectiveTo study and evaluate the application value of HE4, CA125 and PDGF-BB detections for diagnosis and clinical staging of ovarian malignant tumors . Methods216 patients were divided into two groups. Group one (premenopausal group) included 26 cases of malignant ovary tumor and 53 cases of benign ovary tumor, and 60 cases of healthy women as control. Group two (emenopausal group) comprised of 50 cases of malignant ovary tumor, 87 cases of benign ovary tumor and 108 cases of healthy women. HE4, CA125 and PDGF-BB in sera of patients were detected with ICMA and ELISA and the clinical application value in diagnosis of malignant ovarian tumor was analyzed. ResultsThe levels of HE4, CA125 and PDGF-BB in the cases of malignant ovary tumor were significantly higher than those of benign tumors and healthy women (P <0.01). Spearman correlation analysis was staticstically significantly and HE4 was the highest correlation (r=0.613). The sensitivity of HE4 and CA125 was higher than that of PDGF-BB (P <0.05) while no difference was observed between HE4 and CA125 (P>0.05). At the same time, the specificity and accuracy of HE4 reached 88.1% and 87.1%, respectively when the level of 36.5pmol/L was taken as the threshold value in premenopausal group. In the menopausal group, however, the specificity and accuracy were found to be 93.5% and 88.7% respectively if the cut-off value of 56.8pmol/L was used. ConclusionMornitoring of the three seral tumor markers of serum HE4, CA125 and PDGF-BB possesses a practical significance in helping to master the situation of patients, efficacy of treatments, and assessment of prognosis of malignant ovarian tumors.

Key words: Ovarian, neoplasm, Tumor, marker, Human, epididymis, protein, 4, Vascular, endothelial, growth, factor

中图分类号: