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临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (1): 36-38.DOI: 10.3969/j.issn.1671-2587.2019.01.012

• 临床输血 • 上一篇    下一篇

新疆柯尔克孜族人群红细胞ABO、RH系统抗原分布及遗传多态性调查*

朱蓉, 王峰, 梁静, 帕提古丽, 苏来曼, 赖薇兰炯采, 邱芬   

  1. 845350 新疆克孜勒苏柯尔克孜自治州人民医院（朱蓉,帕提古丽.苏来曼,赖薇）;
    新疆阿图什市人民医院（王峰）;
    新疆医科大学第六附属医院（梁静）;
    南方医科大学（兰炯采）;
    新疆伊犁哈萨克自治州奎屯医院（邱芬）
  • 收稿日期:2018-09-20 出版日期:2019-02-20 发布日期:2019-01-28
  • 通讯作者: 邱芬,女,主任检验师,主要从事输血医学及血液免疫学研究,（E-mail）qiufen_kt@163.com。
  • 作者简介:朱蓉（1973-）,女,安徽庐江人,副主任检验师,本科,主要从事临床输血工作,（Tel）13899499911（E-mail）465075000@QQ.com。
  • 基金资助:
    本课题受新疆克孜勒苏柯尔克孜自治州科研项目（No.20160005）资助

Antigen Distribution and Genetic Polymorphism of ABO and RH Blood Systems in Kirgiz Population of Xinjiang Uygur Region

ZHU Rong, WANG Feng, LIANG Jing, et al   

  1. The Hospital of Xinjiang Kezile Su Autonomous Prefecture, Xinjiang, 845350
  • Received:2018-09-20 Online:2019-02-20 Published:2019-01-28

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摘要： 目的 调查新疆地区柯尔克孜族人群ABO和Rh血型的分布;探索柯尔克孜族特殊Rh表型;并研究其与其他民族、区域的差异。方法 以3 440例新疆地区柯尔克孜族健康体检者为研究对象,鉴定ABO正反定型和Rh血型,计算出ABO及Rh血型的期望值、基因及基因组合体频率、抗原频率,并将本研究的ABO及Rh调查值与期望值进行卡方检验后验证Hardy-Weinberg吻合度。结果 新疆地区柯尔克孜族人群ABO血型分布特征为B>O>A>AB,AB型血型比例最低（9.19%）,A、B、O基因频率分别为0.192 2、0.240 7、0.567 1,ABO血型分布符合Hardy-Weinberg平衡定律;RhD阴性比例为2.18%;未检出表型CCdE-;检出该民族不同Rh血型表型：DCcEE（24例,0.70%）、ccdee（61例,0.78%）、ccdEe（8例,0.23%）、 Ccdee（4例,0.12%）、CcdEe（1例,0.03%）、CCdee（1例,0.03%）。结论 新疆柯尔克孜族与迁徙至黑龙江的同种同源民族比较,ABO血型分布有明显差异;检出新疆柯尔克孜族人群Rh表型分布与其他民族不同。

关键词: 新疆柯尔克孜族, 血型, 遗传多态性, 基因频率, 输血

Abstract: Objective To investigate the distribution of ABO and Rh blood groups in the Kirgiz population of Xinjiang region and explore the nationality-featured ABO and Rh phenotypes. Methods A total of 3 440 blood samples of ABO and Rh blood groups were identified in the patients. The value of expectation of ABO and Rh types, genome chimerism frequency and antigen frequency were calculated. The values of survey and expectations were compared for percent of contact area of Hardy-Weinberg. Results The distribution of ABO blood group was B>O>A>AB, and the frequency of AB blood type was the lowest (9.19%) while frequencies of A, B, and O types were 0.192 2, 0.240 7, and 0.567 1, respectively,which coincide with the law of genetic equilibrium. The negative rate of Rh type was 2.18%. No phenotype of CCdE was found but various Rh types were seen, including DCcEE（0.70%）, ccdee（0.78%）, ccdEe（0.23%）, Ccdee（0.12%）, CcdEe（0.03%）, and CCdee（0.03%）. Conclusion The Kirgiz nationality in Xinjiang has characteristic genetic frequency of Rh blood group,and has a different distribution of ABO blood group when compared with the Kirgiz population who have migrated to Heilongjiang, the northeast of China.

Key words: Kirgiz nationality, Blood groups, Genetic polymorphism, Gene frequency, Transfusion

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