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临床输血与检验 ›› 2021, Vol. 23 ›› Issue (2): 181-185.DOI: 10.3969/j.issn.1671-2587.2021.02.010

• 临床输血 • 上一篇    下一篇

受血者与供血者Rh(D、C、c、E、e)抗原相容情况的回顾性分析

王磊, 吴学忠   

  1. 232000 淮南,安徽理工大学第一附属医院(王磊,吴学忠)
  • 收稿日期:2020-01-22 出版日期:2021-04-20 发布日期:2021-04-19
  • 通讯作者: 吴学忠,男,主任技师,硕士,主要从事输血相关研究,(E-mail)wuxuezhong2002@126.com。
  • 作者简介:王磊(1984-),男,安徽淮南人,主管技师,学士,主要从事临床输血相关研究,(E-mail)wl19840816@163.com。

Retrospective Analysis of Rh (D,C, c, E, e) Antigens Compatibility between Blood Recipients and Donors

WANG Lei, WU Xue-zhong   

  1. The First Affiliated Hospital of Anhui University of Science and Technology, Anhui, Huainan 232000
  • Received:2020-01-22 Online:2021-04-20 Published:2021-04-19

摘要: 目的 了解我院受血者及其供血者Rh(D、C、c、E、e)抗原和表型分布,分析受、供者Rh抗原相容情况及其临床意义。方法 收集交叉配血相合的受血者血样418例和供血者血样710例,进行Rh(D、C、c、E、e)抗原检测,比较分析受、供者抗原和表型分布差异及抗原相容性。结果 受、供者Rh(D、C、c、E、e)抗原分布无显著性差异,受、供者CcDEe、CCDee表型分布比例差异有统计学意义(P<0.05)。受、供者Rh(D、C、c、E、e)抗原不相容性输血中以c、E抗原同时不相容占比最高(50.00%);ccDEE、ccDEe和CcDEE表型的受血者发生Rh抗原不相容性输血的概率较高;受血者输注多个供血者血液时,发生Rh抗原不相容性输血的概率最高(P<0.05)。结论 临床输血中存在一定比例的Rh抗原不相容性输血,交叉配血前对受、供者进行Rh(D、C、c、E、e)抗原的检测并采取相容性输血,可有效提升临床输血治疗的安全性。

关键词: 受血者, 供血者, Rh血型, D、C、c、E、e抗原

Abstract: Objective To explore the distribution of Rh(D, C, c, E, e)antigens and phenotypes of blood recipients and their donors in our hospital, and to analyze the compatibility of Rh antigens between recipients and donors as well as its clinical significance. Methods Cross-matching matched blood samples of 418 recipients and 710 donors were collected for Rh (D,C, c, E, e)antigens detection, and the distribution differences of antigens and phenotypes in recipients and donors as well as the antigen compatibility were compared and analyzed. Results There was no significant difference in Rh(D, C, c, E, e) antigens distribution between recipients and donors. The proportion of CcDEe and CCDee phenotype distribution was different between the recipients and the donors(P<0.05). The percentage of simultaneous incompatibility of C and e antigens between blood recipients and donors was the highest(50.00%)among Rh(D, C, c, E, e)antigen-incompatible transfusion. The recipients with ccDEE, ccDEe and CcDEE phenotypes had a higher probability of Rh antigen-incompatible transfusion. The recipients of transfusion from multiple donors had the highest probability of Rh antigen-incompatible transfusion(P<0.05). Conclusion There is a certain proportion of Rh antigen-incompatible transfusion in clinical transfusion. Detection of Rh(D, C, c, E, e)antigens before cross-matching and adoption of compatible transfusion can effectively improve the safety of clinical transfusion.

Key words: Recipients, Donors, Rh blood group, D C c E e antigens

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