血清可溶性髓系细胞触发受体-1在骨折术后感染中的诊断价值

doi:10.3969/j.issn.1671-2587.2019.01.026

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (1): 77-81.DOI: 10.3969/j.issn.1671-2587.2019.01.026

血清可溶性髓系细胞触发受体-1在骨折术后感染中的诊断价值

宋倩

054000 邢台,河北省冀中能源邢台矿业集团总医院检验科

收稿日期:2018-08-14 出版日期:2019-02-20 发布日期:2019-01-28
作者简介:宋倩（1984-）,女,河北石家庄人,主管检验师,主要从事微生物检验工作,（Tel）13730098700。

Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells-1 on Postoperative Infections Following Fractures

SONG Qian

Department of Laboratory,The General Hospital of Hebei Jizhong energy Xingtai Mining Group co.LTD,Xingtai,Hebei,054000

Received:2018-08-14 Online:2019-02-20 Published:2019-01-28

摘要/Abstract

摘要： 目的探讨血清可溶性髓系细胞触发受体-1（sTREM-1）在骨折术后感染中的诊断价值。方法将本院骨科收治的187例骨折患者按照术后感染情况分为感染组34例和非感染组153例,分别于术前1 d、术后即刻和术后24 h采集患者肘静脉血5 mL,采用魏氏法测定红细胞沉降率（ESR）,免疫透射比浊法测定血清C-反应蛋白（CRP）值,免疫化学发光法检测血清降钙素原（PCT）值,酶联免疫吸附试验检测血清sTREM-1值,利用受试者工作曲线（ROC）比较ESR、CRP、PCT、sTREM-1对骨折术后感染的诊断效能。结果与术前1 d比较,感染组和非感染组术后ESR、CRP、PCT、sTREM-1持续升高,不同时间点比较差异具有统计学意义（P﹤0.05）;感染组术后即刻、术后24 h ESR、CRP、PCT、sTREM-1明显高于同时段非感染组,组间差异亦有统计学意义（P﹤0.05）。术前1 d,ESR、CRP、PCT、sTREM-1诊断术后感染的AUC均低于0.7,准确性较低;术后即刻,PCT诊断术后感染的AUC（0.951）高于ESR（0.830）、CRP（0.738）和sTREM-1（0.840）;术后24 h,sTREM-1诊断术后感染的AUC（0.920）高于ESR（0.731）、CRP（0.822）和PCT（0.780）。结论血清PCT可以作为骨折术后感染早期诊断的指标,sTREM-1可以作为判断术后感染病情和病程的重要指标。

关键词: 感染, 红细胞沉降率, C-反应蛋白, 降钙素原, 可溶性髓系细胞触发受体-1

Abstract: Objective To explore the diagnostic value of soluble triggering receptor expressed on myeloid cells-1 （sTREM-1） on postoperative infections following fractures. Methods A total of one hundred and eighty-seven patients with fractures treated in our hospital were divided into infection group （thirty-four cases） and non-infection group （one hundred and fifty-three cases） according to the infection standard,5 mL of veinal blood was collected 1 day before operation,immediate postoperative and 24 h after operation,respectively. The value of ESR was detected by Westergren method,the levels of CRP were measured by immunoturbidimetry assay,the level of PCT was detected by chemiluminescence immunoassay,and the levels of sTREM-1 were measured by enzyme linked immunosorbent assay. The diagnostic value of ESR,CRP,PCT,sTREM-1 for postoperative infections following fractures was performed by receiver operating curve （ROC）. Results Compared to the 1 day before operation,the levels of ESR,CRP,PCT,sTREM-1 in the infection group and non-infection group constantly increasing,there was significant difference between different time points （P﹤0.05）. The levels of ESR,CRP,PCT,sTREM-1 in the infection group were markly higher than that in the non-infection group,the difference between groups was significantly （P﹤0.05）. On the 1 day before operation,the accuracy of ESR,CRP,PCT,sTREM-1 for postoperative infections all were lower （all AUC﹤0.7）. At the moment of immediate postoperative,the AUC of PCT （0.951） higher than ESR （0.830）,CRP （0.738） and sTREM-1 （0.840）. On the 24 h after operation,the AUC of sTREM-1 （0.920） higher than ESR （0.731）,CRP （0.822） and PCT （0.780）. Conclusion Serum PCT can be used as an index for the early diagnosis of postoperative infections following fractures,while sTREM-1 can be used as an index for disease severity and course of infections.

Key words: Infections, Erythrocyte sedimentation rate, C-reactive protein, Procalcitonin, Soluble triggering receptor expressed on myeloid cells-1

中图分类号:

R619⁺.3 R446.11

宋倩. 血清可溶性髓系细胞触发受体-1在骨折术后感染中的诊断价值[J]. 临床输血与检验, 2019, 21(1): 77-81.

SONG Qian. Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells-1 on Postoperative Infections Following Fractures[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2019, 21(1): 77-81.

参考文献

1 李国栋.骨科金属内固定物置入后患者血清C-反应蛋白和红细胞沉降率的变化[J].中国组织工程研究,2015,(25):3967-3971.
2 Strojnik T,Smigoc T,Lah T T. Prognostic value of erythrocyte sedimentation rate and C-reactive protein in the blood of patients with glioma[J].Anticancer Res,2014,34(1):339-347.
3 牛犇,王硕,孙亚,等.C 反应蛋白和红细胞沉降率在中老年患者脊柱内固定术前后的表达[J].中国实验诊断学,2016,(2):291-293.
4 李凡,张伟令,黄东生,等.降钙素原、C反应蛋白在儿童恶性实体瘤并感染及肿瘤进展中的诊断价值[J].中华实用儿科临床杂志,2017,32(10):743-746.
5 Adly A A,Ismail E A,Andrawes N G,et al.Circulating soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as diagnostic and prognostic marker in neonatal sepsis[J]. Cytokine,2014,65(2):184-191.
6 Ravetti C G,Moura A D,Vieira É L,et al.sTREM-1 predicts intensive care unit and 28-day mortality in cancer patients with severe sepsis and septic shock[J].J Crit Care,2015,30(2):7-13.
7 中华人民共和国卫生部.医院感染诊断标准(试行)[J].中华医学杂志,2001,81(5):314-320.
8 Hannigan G D,Hodkinson B P,McGinnis K,et al.Culture-independent pilot study of microbiota colonizing open fractures and association with severity,mechanism,location,and complication from presentation to early outpatient follow-up[J].J Orthop Res,2014,32(4):597-605.
9 张艳平,周鹂婕.C-反应蛋白联合降钙素原对慢性阻塞性肺病急性加重期中细菌感染的诊疗价值[J].中南大学学报(医学版),2014,39(9):939-943.
10 Sbong S,Feldman M. Frequency and causes of C-reactive protein and erythrocyte sedimentation rate disagreements in adults[J]. Int J Rheum Dis,2015,18(1):29-32.
11 Ronde-Oustau C,Diesinger Y,Jenny J Y,et al.Diagnostic accuracy of intra-articular C-reactive protein assay in periprosthetic knee joint infection--a preliminary study[J].Orthop Traumatol Surg Res,2014,100(2):217-220.
12 吴延雷,汪晓英,方正,等.降钙素原与 C-反应蛋白和白细胞计数在新生儿感染性疾病诊断应用[J].中华医院感染学杂志,2014,(24):6063-6065.
13 Liu F,Xiang G,Yuan R,et al.Procalcitonin sensitive detection based on graphene-gold nanocomposite film sensor platform and single-walled carbon nanohorns/hollow Pt chains complex as signal tag[J].Biosens Bioelectron,2014,60(3):210-217.
14 Stein M,Schachter-Davidov A,Babai I,et al.The Accuracy of C-Reactive Protein,Procalcitonin,and s-TREM-1 in the Prediction of Serious Bacterial Infection in Neonates[J]. Clin Pediatr (Phila),2015,54(5):439-444.
15 高东培,李凤艳,谢垒,等.脓毒症患儿血清可溶性髓样细胞触发受体-1、可溶性尿激酶型纤溶酶原激活物受体变化的意义[J].中华实用儿科临床杂志,2015,30(6):433-437.
16 仲美凤,范玉金,朱科研,等.血清CD64、CD54、sTREM-1在儿童细菌性肺炎早期诊断及鉴别中的价值[J].山东医药,2016,56(36):78-80.
17 方策,赵其纯,尚希福,等.降钙素原在类风湿性关节置换术后早期切口感染诊断中的应用[J].安徽医学,2014,35(5):599-601.
18 Schmidt S,Windgassen M,Nofer J R,et al.Procalcitonin as a postmortem sepsis marker. A comparison of the validity of results obtained from blood serum,aqueous humour and cerebrospinal fluid[J].Int J Legal Med,2015,129(1):117-123.
19 范春红,李时悦,范惠群,等.重症肺炎患者血浆可溶性髓样细胞触发受体1与可溶性血红蛋白清道夫受体的水平变化[J].重庆医学,2015,44(34):4780-4783.

[1]	林授, 江伟梅, 詹友知, 林洪铿. 福州地区无偿献血人群HIV-1新近感染情况及分布特征分析^*[J]. 临床输血与检验, 2021, 23(2): 212-215.
[2]	闫松霞, 王海燕, 井忠翠, 侯方, 罗兵. 格林巴利综合征与乙肝病毒感染相关性分析[J]. 临床输血与检验, 2021, 23(2): 222-226.
[3]	中国医师协会输血科医师分会. 医疗机构中乙型肝炎病毒、丙型肝炎病毒、人类免疫缺陷病毒(1+2型)核酸检测策略专家共识[J]. 临床输血与检验, 2020, 22(6): 561-564.
[4]	刘海艇, 邓智华, 蔡丹, 孟芹, 桂嵘, 王勇军, 凌锋, 王海燕, 陈军浩, 王顺, 谢华斌, 黄丽芳, 王占科, 李志波, 程金凤, 焦巍, 唐曙明, 谢小兵, 江小工, 陈亚军, 周红霞, 骆群, 黄远帅, 周明, 吕小英. 10173例检测乙型肝炎标本的血清学与核酸结果分析^*[J]. 临床输血与检验, 2020, 22(6): 583-586.
[5]	徐倩, 姜黎明, 欧阳春. 乙脑病毒E蛋白抗体在THP-1细胞中对增强DENV-Ⅱ感染的作用研究^*[J]. 临床输血与检验, 2020, 22(6): 594-598.
[6]	陈宣宇, 于笑难, 向东. EB病毒感染患者产生类-D同种抗体伴抗-I1例[J]. 临床输血与检验, 2020, 22(6): 643-645.
[7]	汤伟明, 徐燕, 芮志莲. 血清SAA、CK、ET水平在小儿急性感染性腹泻病情评估中的价值*[J]. 临床输血与检验, 2020, 22(5): 530-532.
[8]	王莉, 王小军. 外周血嗜酸性粒细胞与哮喘-慢阻肺重叠的关系研究[J]. 临床输血与检验, 2020, 22(2): 200-202.
[9]	金梅, 马丹冬. 血清丙酸对感染性休克早期诊断及预后的评估价值[J]. 临床输血与检验, 2020, 22(1): 58-63.
[10]	石琼梅, 惠朝晖, 张永顶, 龙国海. 血清降钙素原联合血小板平均体积检测对急性胰腺炎的病情预测价值[J]. 临床输血与检验, 2020, 22(1): 86-88.
[11]	杜春梅, 林杰. HBP及PCT联合检测在小儿呼吸道细菌感染诊断中的价值[J]. 临床输血与检验, 2020, 22(1): 89-91.
[12]	秦丹, 王建斌. 动态监测PCT、CRP水平变化对重型颅脑损伤患者肺部感染的诊断价值[J]. 临床输血与检验, 2020, 22(1): 92-95.
[13]	杨帆, 安晓霞, 程亚华. 血清β-hCG、ICAM-1、MMP-9在足月胎膜早破宫内感染及预后中的临床评价意义[J]. 临床输血与检验, 2020, 22(1): 96-99.
[14]	杨扬. 新蝶呤与经输血传播病毒和其它感染性疾病相关性研究新进展[J]. 临床输血与检验, 2020, 22(1): 109-110.
[15]	李炼, 何蕾. 某三级综合医院4 391例儿童9种呼吸道病原体IgM抗体检测结果分析^*[J]. 临床输血与检验, 2019, 21(6): 616-618.

血清可溶性髓系细胞触发受体-1在骨折术后感染中的诊断价值

Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells-1 on Postoperative Infections Following Fractures

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

关于本刊

作者中心

在线期刊

访问统计

联系我们