• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)
临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (2): 194-197.DOI: 10.3969/j.issn.1671-2587.2019.02.023

• 临床检验 • 上一篇    下一篇

老年人血小板聚集的危险因素分析

黄燕, 李莉, 张珏, 孙健, 张文霞, 蔡峥   

  1. 201203 上海中医药大学附属曙光医院检验科（黃燕,张珏,孙健,张文霞）; 上海第一人民医院检验科（李莉）; 上海曙光医院老年病科（蔡峥）
  • 收稿日期:2018-10-15 出版日期:2019-04-20 发布日期:2019-04-10
  • 通讯作者: 蔡峥,主要从事中西医结合治疗老年心脑血管疾病研究,（E-mail）caizheng201166@163.com。

An Analysis of Risk Factors of Platelet Aggregation in The Elderly

HUANG Yan, LI Li, ZHANG Jue, et al   

  1. Clincal Laboratory of Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203
  • Received:2018-10-15 Online:2019-04-20 Published:2019-04-10

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摘要： 目的 通过血小板聚集功能检测,分析其与老年血栓有关的血小板聚集的危险因素。方法 利用PL-12多参数血小板功能分析仪检测134例老年样本组及56例对照组对花生四烯酸（AA）诱导血小板聚集的最大聚集率（Maximum Aggregation Rate,MAR）及平均聚集率（Average Aggregation Rate,AAR）,分析年龄、性别、血糖（GLU）、低密度脂蛋白（LDL）对MAR及MAR与AAR差值的影响,并与健康人群比较。结果 老年样本组AA诱导的MAR检测值大于80%的比例为39.6%（53/134）,明显高于健康组的14.3%（8/56）;样本组中老年女性AA的MAR高于老年男性（P<0. 05）,其︱MAR-AAR︱差值中位数（3.90）小于男性的中位数（4.85）;样本组中血糖异常且MAR位于风险区的样本比例为41.2%（21/51）,与血糖正常的比例42.2%（35/83）相比,无差异统计学意义,样本组中LDL异常且MAR位于风险区的样本比例为49.4%（44/89）,明显高于LDL正常组的比例22.2%（10/45）（P<0. 01）,同时LDL值与︱MAR-AAR︱也密切相关（R=-0.824,P<0. 05）。结论 年龄、性别、LDL等危险因素影响血小板聚集功能。

关键词: 最大聚集率, 最大聚集率-平均聚集率, 危险因素

Abstract: Objective To analyze the risk factors of thrombogenesis in the elderly population through functional tests of platelet aggregation. Method Tests of the maximum aggregation rate (MAR）and average aggregation rate (AAR) were carried out in 134 old persons. The impact of the age,gender,GLU and LDL on MAR and AAR and the value of their difference was analyzed. Results The ratio over 80 percent of MAR value was 39.6%,which is obviously higher than that (14.3%) in the control,and the ratio in females was higher than that in males (P<0.05). The median difference (3.90) of females was lower than that of males (4.85). No impact of blood glucose (P>0.05) but marked influence of LDL（P<0. 01）was noted on the abnormal value of MAR. Additionally,the value of LDL was closely correlated with the difference of MAR-AAR（R=-0.824,P<0.05）. Conclusion The risk factors of age,gender,as well as LDL level have notable impact on platelet aggregation.

Key words: MAR, Pletlet aggregation, Risk Factors

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