血清白介素-10、胸苷激酶1在急性淋巴细胞白血病患儿中的表达及与危险度分层的相关性

doi:10.3969/j.issn.1671-2587.2022.05.014

临床输血与检验 ›› 2022, Vol. 24 ›› Issue (5): 621-625.DOI: 10.3969/j.issn.1671-2587.2022.05.014

血清白介素-10、胸苷激酶1在急性淋巴细胞白血病患儿中的表达及与危险度分层的相关性

宋春艳, 林云碧, 雷庆龄, 吕瑜, 肖祖刚

650000 昆明医科大学附属儿童医院/昆明市儿童医院血液肿瘤科

收稿日期:2022-02-23 出版日期:2022-10-20 发布日期:2022-10-31
作者简介:宋春艳（1983-）,女,山西长治人,本科,主治医师,主要从事儿童血液肿瘤研究,（E-mail）songdhgd112@163.com。

CSerum Interleukin-10 and Thymidine Kinase 1 Levels and Their Correlation with Risk Stratification in Children with Acute Lymphoblastic Leukemia

SONG Chun-yan, LIN Yun-bi, LEI Qing-ling, et al

Department of Hematology and Oncology, Children's Hospital Affiliated to Kunming Medical University/Kunming Children's Hospital, Kunming, Yunnan 650000

Received:2022-02-23 Online:2022-10-20 Published:2022-10-31

摘要/Abstract

摘要： 目的观察血清白介素（IL）-10、胸苷激酶1（TK1）在急性淋巴细胞白血病（ALL）患儿中的表达情况,并分析二者与ALL患儿危险度分层的关系。方法选取2018年5月~2021年5月医院收治的100例ALL患儿作为研究对象,全部患儿均评估危险度分层,并调查患儿基线资料,检测患儿血清IL-10、TK1等实验室指标,分析血清IL-10、TK1在ALL患儿中的表达情况及其与危险度分层的关系。结果全部患儿均接受危险度分层评估,其中24例标危,50例中危,26例高危,占比分别为24.00%,50.00%,26.00%;3组基线资料对比,差异无统计学意义（P>0.05）;高危组的IL-10、TK1及白细胞（WBC）计数均高于标危组和中危组,且组间两两比较,差异有统计学意义（P<0.05）;采用Kendall's tau-b相关性分析结果显示,ALL患儿血清IL-10、TK1及WBC计数与危险度分层之间呈正相关（r>0,P<0.05）;建立多元Logistic回归分析结果显示,以高危组为参照,血清IL-10、TK1及WBC计数降低时,ALL患儿危险度分层低的可能性分别为7.128倍、13.572倍及1.665倍（P<0.05）。结论血清IL-10、TK1在ALL患儿中存在异常表达,且与危险度分层存在相关性。

关键词: 急性淋巴细胞白血病, 危险度分层, 白介素-10, 胸苷激酶1, 相关性

Abstract: Objective To determine serum interleukin (IL)-10 and thymidine kinase 1 (TK1) levels in children with acute lymphoblastic leukemia (ALL), and analyze the relationship between the two and risk stratification in ALL children. Methods A total of 100 ALL children admitted at hospital from May 2018 to May 2021 were selected. All pediatric patients were evaluated for risk stratification, and we investigated the baseline data. Serum IL-10, TK1, as well as other laboratory indexes were detected. The expression of serum IL-10 and TK1, and the relationship between the two levels and risk stratification were performed. Results ALL children were evaluated for risk stratification, of which 24 cases had standard-risk, 50 cases had medium-risk and 26 cases had high-risk, accounting for 24.00%, 50.00% and 26.00% respectively. There was no statistically significant difference between the three groups of baseline data (P>0.05). The levels of IL-10, TK1 and white blood cell (WBC) count in high-risk group were higher than those in standard-risk group and medium-risk group, and there was a statistically significant differences between the two groups(P<0.05). Using Kendall's tau-b, we found positive correlation between serum IL-10, TK1 and WBC count were associated with risk stratification in ALL children (r>0, P<0.05). Multivariate Logistic regression analysis revealed that when serum IL-10, TK1 and WBC counts decreased, the probability of risk stratification in ALL children was 7.128 times, 13.572 times and 1.665 times, respectively, compared with high-risk group (P<0.05). Conclusions erum IL-10 and TK1 are abnormally expressed in ALL children and are positively correlated with risk stratification.

Key words: Acute lymphoblastic leukemia, Risk stratification, Interleukin-10, Thymidine kinase-1, Correlation

中图分类号:

R733.71

宋春艳, 林云碧, 雷庆龄, 吕瑜, 肖祖刚. 血清白介素-10、胸苷激酶1在急性淋巴细胞白血病患儿中的表达及与危险度分层的相关性[J]. 临床输血与检验, 2022, 24(5): 621-625.

SONG Chun-yan, LIN Yun-bi, LEI Qing-ling, et al. CSerum Interleukin-10 and Thymidine Kinase 1 Levels and Their Correlation with Risk Stratification in Children with Acute Lymphoblastic Leukemia[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(5): 621-625.

参考文献

[1] AMANKWAH E K,DEVIDAS M,TEACHEY D T,et al.Six candidate miRNAs associated with early relapse in pediatric B-cell acute lymphoblastic leukemia[J]. Anticancer Res,2020,40(6):3147-3153.
[2] STUTTERHEIM J,VAN DER SLUIS I M,DE LORENZ O P,et al.Clinical implications of minimal residual disease detection in infants with KMT2A-rearranged acute lymphoblastic leukemia treated on the interfant-06 protocol[J]. J Clin Oncol,2021,39(6):652-662.
[3] TOMIZAWA D,MIYAMURA T,IMAMURA T,et al.A risk-stratified therapy for infants with acute lymphoblastic leukemia:a report from the JPLSG MLL-10 trial[J]. Blood,2020,136(16):1813-1823.
[4] WHITEHEAD T P,WIEMELS J L,ZHOU M,et al.Cytokine levels at birth in children who developed acute lymphoblastic leukemia[J]. Cancer Epidemiol Biomarkers Prev,2021,30(8):1526-1535.
[5] 陆小云,张焕新. 急性白血病血清sICAM-1、IL-10和TNF-α水平变化及临床意义[J].临床血液学杂志,2020,33(11):762-766.
[6] 刘佳,江振洲,张陆勇.急性淋巴细胞白血病发病机制和药物研究进展[J].药物评价研究,2019,42(10):2100-2105.
[7] 江雯,纪玉清,王谦,等.血清胸苷激酶1在骨肉瘤疗效评价中的临床应用[J].检验医学与临床,2019,16(24):3557-3559.
[8] 中华医学会儿科学分会血液学组,《中华儿科杂志》编辑委员会.儿童急性淋巴细胞白血病诊疗建议(第四次修订)[J].中华儿科杂志,2014,52(9):641-644.
[9] 国家卫生计生委医政医管局.国家临床路径(儿科部分)[M].北京:人民卫生出版社,2018:174-175.
[10] BAI J,LI L J,LI Y,et al.Methylation of the promoter region of the MTRR gene in childhood acute lymphoblastic leukemia[J].Oncol Rep,2019,41(6):3488-3498.
[11] DAI Q K,ZHANG G,YANG H,et al.Clinical features and outcome of pediatric acute lymphoblastic leukemia with low peripheral blood blast cell count at diagnosis[J]. Medicine,2021,100(4):e24518.
[12] BURNS M A,PLACE A E,STEVENSON K E,et al.Identification of prognostic factors in childhood T-cell acute lymphoblastic leukemia:results from DFCI ALL Consortium Protocols 05-001 and 11-001[J].Pediatr Blood Cancer,2021,68(1):e28719.
[13] VALLE-REYES S,DOBROVINSKAYA O,PELAYO R,et al.Acute lymphoblastic leukemia cell lines in immunology research[J].Trends Immunol,2021,42(3):182-185.
[14] 周莉蓉,王琪,麦碧薇,等.血清IL-6、IL-10水平与血液肿瘤患儿化疗期间感染程度的相关性[J]. 中华医院感染学杂志,2020,30(15):2381-2385.
[15] 江倩,李宗儒. 微小残留病在急性淋巴细胞白血病中的意义[J]. 临床血液学杂志,2020,33(3):151-156.
[16] 李晓丽,赵艳辉.PTEN基因对急性淋巴细胞白血病细胞增殖、侵袭及迁移的影响[J].山东医药,2019,59(22):16-19.
[17] 朱聪惠,陈任安,乔丹.地西他滨治疗骨髓增生异常综合征的疗效及其对血清LIF、TIM-3、TK-1水平的影响[J]. 检验医学与临床,2021,18(24):3565-3567.
[18] 高丽峰,苗晶. 卵巢上皮癌手术癌组织蛋白激酶B及术后患者血清胸苷激酶1表达与预后的相关性分析[J]. 中国性科学,2021,30(1):47-51.
[19] 宋晓梅,李化,舒莉萍.急性淋巴细胞白血病患儿细胞因子水平与疾病状态的关系研究[J].国际检验医学杂志,2021,42(15):1816-1820.
[20] 詹飞,何倩.IL-2和IL-10在急性髓性白血病患儿血清中的水平及其临床意义[J].实用癌症杂志,2017,32(12):1946-1948.
[21] 穆雪峰,康文全,丁巍,等. 血清胸苷激酶1对老年大肠癌的预测及术后监测效果评价[J].国际老年医学杂志,2021,42(1):43-45.

血清白介素-10、胸苷激酶1在急性淋巴细胞白血病患儿中的表达及与危险度分层的相关性

CSerum Interleukin-10 and Thymidine Kinase 1 Levels and Their Correlation with Risk Stratification in Children with Acute Lymphoblastic Leukemia

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