PRP治疗踝关节创伤性滑膜炎疗效观察*

doi:10.3969/j.issn.1671-2587.2022.06.009

临床输血与检验 ›› 2022, Vol. 24 ›› Issue (6): 725-729.DOI: 10.3969/j.issn.1671-2587.2022.06.009

PRP治疗踝关节创伤性滑膜炎疗效观察^*

魏燕, 刘宽, 李祥军, 彭娟, 王瑞含, 刘久波

442000 湖北医药学院附属太和医院输血科（魏燕,彭娟,刘久波）; 湖北医药学院附属太和医院骨伤科（刘宽）; 湖北医药学院附属太和医院创面修复和皮肤外科（李祥军）; 天津医科大学第二医院检验科（王瑞含）

收稿日期:2022-07-19 发布日期:2023-01-05
通讯作者: 刘久波,男,主任医师,教授,主要从事临床输血方面研究,（E-mail）ljb169168@sina.com。
作者简介:魏燕（1981-）,女,湖北十堰人,硕士,主要从事肿瘤分子诊断方面研究,（E-mail）mangolxj@163.com。
基金资助:
*本课题受湖北省卫生健康委2019年输血专项-重点项目（No.WJ2019H344）资助

Observation on the Therapeutic Effect of PRP in the Treatment of Traumatic Synovitis of Ankle Joint

WEI Yan, LIU Kuan, LI Xiang-jun, et al

Department of Blood Transfusion, Taihe Hospital Affiliated to Hubei University of Medical, Shiyan, Hubei 442000

Received:2022-07-19 Published:2023-01-05

摘要/Abstract

摘要： 目的探究富血小板血浆（platelet rich plasma , PRP）治疗踝关节创伤性滑膜炎的效果。方法纳入2021年1月~2022年6月在某三甲医院骨伤科就诊的45例踝关节创伤性滑膜炎患者,按随机数字表法将患者随机分为观察组（20例,行PRP注射治疗）和对照组（25例,行类固醇激素注射治疗）。分别比较两组患者治疗前、治疗后1个月、治疗后3个月、治疗后6个月踝关节评分及临床效果。结果两组患者治疗1个月后Baird-Jackson评分和AOFAS评分均较治疗前升高（P<0.05）、VAS评分较治疗降低（P<0.05）;且对照组优于观察组（P<0.05）。治疗3个月后,对照组Baird-Jackson评分和AOFAS评分较治疗后一个月降低（P<0.05）、VAS评分较治疗后一个月升高（P<0.05）;观察组Baird-Jackson评分和AOFAS评分较治疗后一个月升高（P<0.05）、VAS评分较治疗后一个月降低（P<0.05）,优于对照组（P<0.05）。对照组初次见效时间多见于治疗后24 h,观察组初次见效时间多见于治疗后2周和一月后（P<0.05）。观察组患者的治疗总有效率为95%,高于对照组的68%（P<0.05）。结论传统激素治疗起效快,但维持时间短且易复发;PRP长期效果更好并可持续改善患者临床症状长达6个月,值得临床推广应用。

关键词: 富血小板血浆, 踝关节, 创伤性滑膜炎, 类固醇激素

Abstract: Objective To explore the effect of platelet rich plasma (PRP) on traumatic synovitis of ankle joint. Methods From January 2021 to June 2022, 45 patients with traumatic synovitis of the ankle joint who were treated in the department of orthopedics and traumatology of a tertiary hospital were included. The patients were randomly divided into the observation group (20 cases, PRP treatment) and the control group (25 cases, traditional corticosteroid treatment) according to the random number table method. The ankle joint scores and clinical effects were compared between the two groups at before, 1, 3 and 6 months after treatment. Results The Baird-Jackson score and AOFAS score were higher (P<0.05) and VAS score was lower than before treatment in both groups after 1 month of treatment (P<0.05), and the control group was better than observation group (P<0.05). After 3 months of treatment, Baird-Jackson score and AOFAS score decreased (P<0.05) and VAS score increased (P<0.05) in the control group compared with one month after treatment. Baird-Jackson score and AOFAS score increased (P<0.05) and VAS score decreased (P<0.05) in the observation group compared with one month after treatment ( P<0.05), which was better than the control group (P<0.05). Time to first improvement in the control group was more common in 24 hours after treatment, and which was more common in 2 weeks and 1 month after treatment in the observation group (P<0.05). The total effective rate of the observation group was 95%, higher than that in the control group of 68% (P<0.05). Conclusion Traditional hormone therapy is fast-acting but short-sustained and prone to recurrence. PRP has better long-term effects and can improve patients' clinical symptoms for up to 6 months, which is worthy of clinical application.

Key words: Platelet Rich Plasma, Ankle joint, Traumatic synovitis, Corticosteroid

中图分类号:

R874.5

魏燕, 刘宽, 李祥军, 彭娟, 王瑞含, 刘久波. PRP治疗踝关节创伤性滑膜炎疗效观察^*[J]. 临床输血与检验, 2022, 24(6): 725-729.

WEI Yan, LIU Kuan, LI Xiang-jun, et al. Observation on the Therapeutic Effect of PRP in the Treatment of Traumatic Synovitis of Ankle Joint[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(6): 725-729.

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PRP治疗踝关节创伤性滑膜炎疗效观察^*

Observation on the Therapeutic Effect of PRP in the Treatment of Traumatic Synovitis of Ankle Joint

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