嗜酸性粒细胞在组织损伤修复中的研究进展*

doi:10.3969/j.issn.1671-2587.2026.03.023

临床输血与检验 ›› 2026, Vol. 28 ›› Issue (3): 445-450.DOI: 10.3969/j.issn.1671-2587.2026.03.023

嗜酸性粒细胞在组织损伤修复中的研究进展*

陈浩南^1,2, 闫滢³, 李明²

¹蚌埠医科大学,安徽蚌埠 233030;
²中国科学技术大学附属第一医院检验科,安徽合肥 230031;
³中国科学技术大学附属第一医院肿瘤内科,安徽合肥 230031

收稿日期:2025-07-16 出版日期:2026-06-20 发布日期:2026-07-07
通讯作者: 李明,主要从事嗜酸性粒细胞与肿瘤免疫研究,（E-mail）lm831216@ustc.edu.cn。
作者简介:陈浩南,主要从事嗜酸性粒细胞与急性损伤研究,（E-mail）chnhowdy@163.com。
基金资助:
^{^*}本课题受安徽省自然科学基金项目（No.2408085MH203）、安徽省高等学校科学研究项目（No.2024 AH052063）资助

Research Advances in Eosinophils in Tissue Injury Repair

CHEN Haonan^1,2, YAN Ying³, LI Ming²

¹School of Laboratory Medicine, Bengbu Medical University, Bengbu 233030;
²Department of Laboratory Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230031;
³Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230031

Received:2025-07-16 Online:2026-06-20 Published:2026-07-07

摘要/Abstract

摘要： 嗜酸性粒细胞是一种在人体中含量较少但在机体免疫和炎症过程中发挥重要作用的免疫细胞,通常被认为与过敏性疾病和寄生虫感染相关。近年来,关于嗜酸性粒细胞在不同组织微环境中介导损伤修复的机制逐渐清晰,嗜酸性粒细胞在肿瘤微环境及其在组织损伤修复过程中的调控作用已成为研究的前沿领域。本文对嗜酸性粒细胞在多种组织损伤中的作用及其潜在机制进行综述,旨在为相关疾病的早期筛查、治疗和预防提供新的理论依据和思路。

关键词: 嗜酸性粒细胞, 组织损伤, 炎症, 免疫调节

Abstract: Eosinophils are a subset of immune cells with low abundance in humans but play critical roles in immune regulation and inflammation, traditionally associated with allergic diseases and parasitic infections. Recent studies have increasingly clarified their mechanisms in mediating damage repair within distinct tissue microenvironments. The regulatory roles of eosinophils in tumor microenvironment and tissue damage repair have emerged as cutting-edge research areas. This review systematically summarizes the functional contributions of eosinophils in multiple tissue injuries and their underlying mechanisms, aiming to provide novel theoretical basis and insights for early screening, treatment, and prevention of related diseases.

Key words: Eosinophils, Tissue damage, Inflammation, Immune regulation

中图分类号:

R392.12

陈浩南, 闫滢, 李明. 嗜酸性粒细胞在组织损伤修复中的研究进展*[J]. 临床输血与检验, 2026, 28(3): 445-450.

CHEN Haonan, YAN Ying, LI Ming. Research Advances in Eosinophils in Tissue Injury Repair[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2026, 28(3): 445-450.

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嗜酸性粒细胞在组织损伤修复中的研究进展*

Research Advances in Eosinophils in Tissue Injury Repair

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