红细胞储存损伤研究进展

doi:10.3969/j.issn.1671-2587.2026.03.024

临床输血与检验 ›› 2026, Vol. 28 ›› Issue (3): 451-456.DOI: 10.3969/j.issn.1671-2587.2026.03.024

• 综述 • 上一篇

红细胞储存损伤研究进展

杨楠^1,2, 宁应之², 于鹏², 张晓萍¹

¹甘肃省人民医院,甘肃兰州 730050;
²西北师范大学,甘肃兰州 730070

收稿日期:2025-08-12 出版日期:2026-06-20 发布日期:2026-07-07
通讯作者: 张晓萍,主要从事临床输血方面研究,（E-mail）1150333418@qq.com。
作者简介:杨楠,主要从事临床输血方面研究,（E-mail）892157046@qq.com。并列第一作者：宁应之,主要从事生物多样性、发育生物学等方面研究,（E-mail）skyb514@qq.com。

Research Progress on Red Blood Cell Storage Lesion

YANG Nan^1,2, NING Yingzhi², YU Peng², ZHANG Xiaoping¹

¹Gansu Province People Hospital, Lanzhou 730050;
²Northwest Normal University, Lanzhou, Gansu 730070

Received:2025-08-12 Online:2026-06-20 Published:2026-07-07

摘要/Abstract

摘要： 红细胞输注是治疗贫血和出血性休克的重要手段,但随着储存时间延长,红细胞会经历一系列生化和代谢变化,称为“储存损伤”。这种损伤可能导致氧携带能力下降、增加溶血风险及氧化应激,进而影响患者的临床结果。近年来,储存损伤的影响逐渐引起关注,特别是在与输血相关的不良事件方面。尽管输注存储损伤红细胞的临床预后存在争议,但越来越多的证据表明,较长储存时间的红细胞与不良临床结果相关,如感染风险增加、器官功能障碍和死亡率升高。因此,在血液供应紧张的背景下,合理管理红细胞储存时间和研究新技术以延长红细胞活性成为关键。未来应加强对红细胞储存损伤机制的研究,优化输血方案,并提升血液供应量,以确保患者的安全和有效治疗。

关键词: 红细胞, 储存损伤, 临床预后

Abstract: Red blood cell (RBC) transfusion remains a cornerstone of therapy for the management of anemia and hemorrhagic shock. However, during ex vivo storage, RBCs undergo progressive biochemical and metabolic alterations, a phenomenon termed "storage lesion". Such lesions can impair oxygen-carrying capacity, increase hemolysis risk, and exacerbate oxidative stress, thereby exerting adverse effects on patients' clinical outcomes. In recent years, the impact of storage lesion has attracted growing attention, particularly with respect to adverse events associated with blood transfusion. Although the clinical prognosis of transfusing stored, damaged RBCs remains controversial, accumulating evidence indicates that RBCs with longer storage time are associated with adverse clinical outcomes, including an increased risk of infection, organ dysfunction, and higher mortality rates. Therefore, in the context of tight blood supply, the rational management of RBCs storage time and research on new technologies to preserve RBC viability have become crucial. In the future, efforts should focus on elucidating the mechanisms underlying RBC storage lesion, optimizing transfusion plan, and expanding blood supply to ensure the safety of patients and the efficacy of transfusion therapy.

Key words: Red blood cell, Storage lesion, Clinical prognosis

中图分类号:

R457.1R331.1⁺41

杨楠, 宁应之, 于鹏, 张晓萍. 红细胞储存损伤研究进展[J]. 临床输血与检验, 2026, 28(3): 451-456.

YANG Nan, NING Yingzhi, YU Peng, ZHANG Xiaoping. Research Progress on Red Blood Cell Storage Lesion[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2026, 28(3): 451-456.

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红细胞储存损伤研究进展

Research Progress on Red Blood Cell Storage Lesion

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