刺激响应型红细胞仿生纳米载体的研究进展*

doi:10.3969/j.issn.1671-2587.2023.02.024

临床输血与检验 ›› 2023, Vol. 25 ›› Issue (2): 282-288.DOI: 10.3969/j.issn.1671-2587.2023.02.024

• 综述 • 上一篇

刺激响应型红细胞仿生纳米载体的研究进展^*

强书毓, 彭东新, 董晏榕, 詹林盛, 孙苏静, 王小慧

100850 北京,中国人民解放军军事科学院军事医学研究院卫生勤务与血液研究所

收稿日期:2023-01-11 发布日期:2023-04-25
通讯作者: 王小慧,研究员,主要从事输血安全与纳米生物技术研究,（E-mail）lovechina1980@163.com。
共同通信作者：孙苏静,主要从事输血免疫学相关研究,（E-mail）ammsreb@163.com。
作者简介:强书毓,主要从事纳米生物学方面研究,（E-mail）ziyushuyu@163.com。
并列第一作者：彭东新,主要从事纳米生物学方面研究,（E-mail）571651960@qq.com。
基金资助:
*本课题受国家自然科学基金青年科学基金项目（No.81903624）资助

Received:2023-01-11 Published:2023-04-25

摘要/Abstract

摘要： 红细胞是最常用的天然药物载体,具有很多优势：可以逃脱免疫系统清除,进而延长体内循环半衰期;红细胞内部血红蛋白、过氧化氢酶等协同运作,可增加治疗效果;来自机体的红细胞,其可随血液运输、无障碍穿过组织,具有高生物相容性,副作用低,载药容量大等特点。因此,近年来红细胞载药系统得到较为深入的研究。但其精准靶向释药仍是临床研究的难点,因此,设计新颖有效的刺激响应型红细胞仿生纳米载体,成为红细胞载药相关研究的重点堵点问题。目前,其刺激响应型手段主要包括外源性刺激（光、声、磁、电等）和内源性刺激（酶、pH、ROS等）,本文对红细胞仿生纳米载体的不同刺激响应型设计的原理、方法、应用等进行总结和分析。

中图分类号:

R331.1⁺41

强书毓, 彭东新, 董晏榕, 詹林盛, 孙苏静, 王小慧. 刺激响应型红细胞仿生纳米载体的研究进展^*[J]. 临床输血与检验, 2023, 25(2): 282-288.

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