基于代谢组学的红细胞贮存损伤相关研究新进展*

doi:10.3969/j.issn.1671-2587.2022.03.025

临床输血与检验 ›› 2022, Vol. 24 ›› Issue (3): 403-408.DOI: 10.3969/j.issn.1671-2587.2022.03.025

• 综述 • 上一篇

基于代谢组学的红细胞贮存损伤相关研究新进展^*

王欢, 徐方, 郭建荣

200135 上海,海军军医大学附属公利医院麻醉与围术期医学部（王欢,郭建荣）; 宁夏医科大学基础医学院（徐方）

收稿日期:2022-02-18 出版日期:2022-06-20 发布日期:2022-06-22
通讯作者: 郭建荣,男,主任医师,博士生导师,主要从事围术期输血与血液保护研究,（E-mail） jianrguo@126.com。
作者简介:王欢（1982-）,女,副主任医师,在读博士研究生,主要从事围术期输血与血液保护研究,（E-mail）wh07090 @glhospital.com。
基金资助:
*本课题受国家自然科学基金项目（No.81900183、No.81870147）、上海市浦东新区卫生系统新兴交叉学科建设项目（No.PWXx2020-05）资助

Received:2022-02-18 Online:2022-06-20 Published:2022-06-22

摘要/Abstract

摘要： 组学技术是通过超高通量定量跟踪标记底物的实验研究方法,从整体角度出发分析人类组织器官功能和代谢的状态。代谢组学定量研究了在外界不同刺激情况下红细胞代谢物的生理和病理变化,不同代谢物的代谢调节通路。本文深入探究红细胞在体外贮存期间氨基酸、铁、一氧化氮、糖和脂质代谢等能量代谢和氧化损伤的变化,扩大了对于代谢贮存损伤机制的理解,明确红细胞代谢物与机体生理、病理变化的相对潜在关系,为个性化体外红细胞贮存如定制添加剂、研发不同的红细胞贮存液提供思路。

关键词: 输血, 红细胞贮存损伤, 组学, 代谢

王欢, 徐方, 郭建荣. 基于代谢组学的红细胞贮存损伤相关研究新进展^*[J]. 临床输血与检验, 2022, 24(3): 403-408.

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基于代谢组学的红细胞贮存损伤相关研究新进展^*

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