关键词: 中性粒细胞, 粒细胞缺乏, 感染, 化疗, 骨髓抑制

Abstract: Objective To understand the effect of donor granulocyte collection and transfusion in the case of non mobilization,whether it is able to support the anti infection treatment of bone marrow suppression in patients with hematological diseases undergoing chemotherapy.Methods The peripheral blood by using COM.TEC blood cell separator was used to collect neutral granulocyte of 14 donors from peripheral blood.,Donor granulocytes were infused to hematological disease patients with bone marrow suppression after chemotherapy.Thenblood cell counts and body temperature were observed after the infusion. The blood cell counter was used to count number of cells in product.Results The granulocyte count can reach 1×10¹⁰/L in the product, but it is much lower than （10.3~14.4）×10¹⁰/L after the mobilization of the colony stimulating factor (G-CSF) which is mentioned in the literature. But efficient rate of hematological disease patients with agranulocytosis reached 85.7% after infusion.Conclusion Non mobilization of donor granulocyte acquisition can support the patient's anti infection treatment.

Key words: Granulocyte, Agranulocytosis, Infection, Chemotherapy, Arrest, of, bone, marrow