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临床输血与检验

临床输血与检验 ›› 2016, Vol. 18 ›› Issue (2): 140-143.DOI: 10.3969/j.issn.1671-2587.2016.02.016

• 临床检验研究 • 上一篇    下一篇

Th22细胞在急性淋巴细胞白血病患者外周血的表达变化及临床意义

曹慧琴,韦玮   

  1. 716000 陕西省延安市延安大学附属医院血液科
  • 收稿日期:2015-09-25 修回日期:2016-09-21 出版日期:2016-04-20 发布日期:2016-09-21
  • 作者简介:曹慧琴（1982–）,女,陕西榆林人,主治医师,学士,主要从事血液病研究,（Tel）18829395833。

Expression of Th22 Cytokines and Its Significance in Patients with Acute Lymphoblastic Leukemia

CAO Hui-qin, WEI Wei   

  1. Yanan University Affiliated Hospital 716000
  • Received:2015-09-25 Revised:2016-09-21 Online:2016-04-20 Published:2016-09-21

PDF

611

被引次数

1

摘要： 目的探索急性淋巴细胞白血病（acute lymphoblastic leukemia,ALL）患者Th22细胞及其细胞因子的表达改变及临床意义。方法分析2008年1月~2014年1月在本院接受治疗的ALL患者的临床资料,作为观察组;另外纳入健康体检者作为对照组。比较两组Th22细胞及细胞因子的表达水平,及观察组患者治疗前后的指标变化;分析观察组患者治疗前血清细胞因子间的相关性。结果本研究共纳入研究对象78例,其中观察组43例,对照组35例。观察组患者血液Th22细胞、TNF-α、IL-6及IL-22水平显著低于对照组（P<0.001）;TGF-β水平显著高于对照组（P<0.001）。治疗后观察组Th22细胞、TNF-α、IL-6及IL-22水平较治疗前显著上升（P<0.001）;血清TGF-β水平较治疗前显著下降（P<0.001）。Pearson检验显示观察组患者IL-22水平与TNF-α水平呈现正相关（r=0.699,P<0.001）;而IL-22水平与TGF-β水平呈现负相关（r=-0.731,P<0.001）。以治疗后患者Th22细胞水平的中位数（0.71%）为界将患者分为A（≥0.71）、B（<0.71）两组。A组患者治疗后1年累积复发率低于B组（9.09%,2/22 vs 38.10%,8/21;Log-rank χ2=3.963,P=0.047）。结论急性淋巴白血病患者外周血Th22及细胞因子（IL-22）表达下降,经治疗后可上升,IL-22水平可用以辅助判断疾病活动性及监测治疗效果。

关键词: 急性淋巴细胞白血病, 细胞因子, T淋巴细胞, 化疗

Abstract: ObjectiveThe study was aimed to analyze the changing expression levels of Th22 Cells and its cytokines in patients with acute lymphoblastic leukemia and its clinical significance. MethodsClinical data of patients with acute lymphoblastic leukemia received treatment at our hospital from 2008 to 2014 was analyzed as Group A. The healthy controls were enrolled as Group B. ResultsA total of 78 patients were analyzed, Group A consisted of 43 cases and Group B 35 cases. Group A had lower level of Th22 cells, TNF-α, IL-6 and IL-22 than these of Group B (P<0.001), and had a higher levels of TGF-β than that of Group B (P<0.001). After treatment, Group A patients had a significant improvement in Th22 cells, TNF-α, IL-6 and IL-22 (P<0.001), and a great decrease in TGF-β (P<0.001). The correlation analysis indicated the level of IL-22 Group A had a significant positive correlation with the level of TNF-α (r =0.699,P<0 .001), and a significant negative correlation with the level of TGF-β (r =-0.731,P<0.001). Group A patients were divided into two groups by the levels of Th22 cells as Group A1 (≥0.71) and Group A2 (<0.71). Group A1 patients had lower recurrence rate than that of Group A2 (9.09%,2/22 vs 38.10%,8/21;Log-rank χ2 =3.963,P =0.047). ConclusionThe decrease of Th22 cells and down-regulation of IL-22 expression level may be related with pathogenesis of acute lymphocytic leukemia, and can be used in evaluating treatment effects.

Key words: Acute, lymphocytic, leukemia, Cytokines, T, lymphocyte, Chemotherapy

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