• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)
临床输血与检验

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (5): 518-521.DOI: 10.3969/j.issn.1671-2587.2018.05.020

• 临床检验 • 上一篇    下一篇

不同分期的慢性肾脏疾病患者贫血及铁代谢指标的研究分析*

陈鹤, 张敏, 赵燕, 徐元宏   

  1. 230022 合肥,安徽医科大学第一附属医院检验科
  • 收稿日期:2018-06-12 出版日期:2018-10-20 发布日期:2018-09-27
  • 通讯作者: 徐元宏,男,教授,主任技师,博士生导师,主要从事临床微生物研究,（E-mail）xyhong1964@163.com。
  • 作者简介:陈鹤（1990-）,男,检验技师,硕士,主要从事临床检验工作,（E-mail）amuchenhe@sina.com。
  • 基金资助:
    *本课题受安徽省高等学校自然科学研究重点项目（No.KJ2017A208）资助

Study on Relation of the Morbidity of Anemia and Iron Metabolism Indexes in Patients with Different Chronic Kidney Disease Stages

CHEN He, ZHANG Min, ZHAO Yan, etal   

  1. The First Affliated Hospital of Anhui Medical University Hefei 230022
  • Received:2018-06-12 Online:2018-10-20 Published:2018-09-27

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摘要： 目的 探究在慢性肾脏病（CKD）患者不同分期贫血和铁代谢指标的差异。方法 将2016年~2017年来本院进行治疗的CKD患者205例纳入研究,测定 CKD各期患者的RBC、Hb、HCT、SF、SI、STF、UIBC、TIBC指标,比较CKD2、3、4、5各期贫血及铁代谢指标的差异。结果 CKD不同分期的贫血率分别为：CKD2期14.8%,CKD3期44.8%,CKD4期79.1%,CKD5期98.7%,差异有统计学意义（χ2=85.59,P<0.05）。CKD不同分期铁代谢指标差异均有统计学意义（P<0.05）。再经组间两两比较显示：RBC和Hb随着病情的进展不断降低。CKD5期与其他期相比,SF明显增高,STF低于其他期,而CKD2、3、4期组间SF则无统计学意义。在CKD4、5期SI水平明显降低。结论 不同分期的慢性肾病患者存在不同程度贫血与铁代谢密切相关;且贫血及铁代谢指标有差异与疾病严重程度相关,有助于肾病患者病情监测和临床的诊断及治疗。

关键词: 铁代谢, 慢性肾脏病, 贫血

Abstract: Objective To explore the differences of anemia rate and iron metabolism indexes among patients with different chronic kidney disease （CKD） stages. Methods 205 patients with CKD,admitted into our hospital from 2016 to 2017,were recruited in this study. Red blood cell （RBC）,Hb,HCT,SF,SI,STF,UIBC and TIBC were measured respectively in the patients with various CKD stages. The statistical analyses were performed in terms of anemia rate and iron metabolism indexes among CKD 2,3,4 and 5 stages. Results The anemia rates in the indicated CKD stages presented respectively： CKD 2,14.8%; CKD 3,44.8%; CKD 4,79.1%; CKD 5,98.7%. There were significant differences in anemia rate and iron metabolism indexs among the five CKD stages （P<0.05）. From CKDs 2 to 5,the levels of RBC and Hb decreased with disease progression .Compared with other stages,SF was significantly increased in CKD5,while STF was lower in CKD5 than in other stages. In CKD4 and 5,SI significantly decreased. Conclusion CKD patients with different stages had different degrees of anemia,which was closely related to iron metabolism. Moreover,there were differences in anemia and iron metabolism,which were relevant with the severity of the disease and may be helpful for clinical diagnosis and treatment.

Key words: Iron metabolism, CKD, Anemia

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