关键词: 小细胞肺癌, 远期生存, 凝血功能, 癌胚抗原, 相关性

Abstract: Objective To study the relationship between coagulation parameters and carcinoembryonic antigen （CEA） expression in patients with small cell lung cancer （SCLC）. Methods From January 2009 to June 2012,120 patients with small cell lung cancer （SCLC） who were admitted to our hospital during that period were selected as the study object and set up as the lung cancer group and 100 healthy volunteers who underwent the physical examination in our hospital at the same time as the control group. We collected blood samples of all the subjects to determine the expression level of carcinoembryonic antigen,coagulation function index,and compared the expression level of carcinoembryonic antigen between lung cancer group and control group. Coagulation function index. The patients with small cell lung cancer were followed up for 5 years. According to their 5-year survival,the patients were divided into survival group and death group. The expression level of carcinoembryonic antigen （CEA） and coagulation function were measured and compared during 5 years follow-up. The expression level of carcinoembryonic antigen （CEA） was analyzed. Results The expression levels of carcinoembryonic antigen and fibrinogen in lung cancer group were higher than those in control group （P<0.05）. The prothrombin time and activated partial thromboplastin time were shorter than those in the control group （P<0.05）. The expression levels of carcinoembryonic antigen and fibrinogen in the dead group were higher than those in the survival group （P<0.05）,and the prothrombin time was higher than that in the survival group. The activated partial thromboplastin time was shorter than that of survival group （P<0.05）. The expression of carcinoembryonic antigen （CEA） and fibrinogen levels were negatively correlated with the long-term survival of patients with small cell lung cancer （SCLC） and prothrombin time （prothrombin time）. The activated partial thromboplastin time was positively correlated with the long-term survival of patients with small cell lung cancer. Conclusion The blood status of patients with small cell lung cancer is generally in hypercoagulability and coagulation function index. The expression level of carcinoembryonic antigen is closely related to its long-term survival. The coagulation function index and carcinoembryonic antigen expression level can be used as a reference index to predict the prognosis of patients with small cell lung cancer.

Key words: Small cell lung cancer, Long-term survival, Coagulation function, Carcinoembryonic antigen, Correlation