Abstract: Objective To analyze the influencing factor of vasovagal reaction in whole blood donors.Methods Blood donors who had experienced vasovagal reactions were collected in 2017. The correlation of extents and types of the reactions with gender,age and frequency of donations were analyzed.Results Among 118 370 blood donors,850 person-times （0.72%） were found to have vasovagal reactions,which varied significantly in gender （male：0.54%; female：1.2%）,age （0.84% in those below 30y and 0.53% in those over or equal to30 y） and frequency of donations （0.78% in first donation and 0.52% in second donation） （P<0.01）. The reactions mostly occurred lightly（94.37%） in the donors,showing pale,perspiration and dizziness after blood collection（P<0.05）.Conclusion The young females have a predisposition to vasovagal reaction on the first donation. Preventive measures should be taken to maintain a stable pool of blood donors.

Key words: Vasovagal reaction, Blood donor, Influencing factors