Abstract: Objective Based on the interference of two cases of passenger lymphocyte syndrome（PLS）after minor ABO-incompatible liver transplantation to cross-matching test and clinical blood transfusion,this paper intends to establish a preliminary monitoring process of PLS after minor ABO-incompatible solid organ transplantation and to explore the blood transfusion strategy of PLS patients under this process. Methods The registration form of solid organ transplant patient information was established, and the basic information of transplant patients （including age,sex,primary disease,ABO and RhD blood group,operation name,operation time,etc.） and basic donor information（including age,sex,ABO and RhD blood type,disease history,etc.）were collected. The yellow staining of skin, the levels of hemoglobin value and other hemolytic indicators（serum bilirubin level,reticulocyte count,LDH,haptoglobin value,direct antiglobulin test results,etc.）,and the results of antibody screening were dynamically monitored and recorded. Results The establishment of post-transplant PLS monitoring process can be used to early diagnose and interfere with PLS. We can timely adjust the blood transfusion strategy according to the changes of monitoring indexes,screen and prepare appropriate blood components for patients,avoid the progressive decrease of postoperative hemoglobin and improve the prognosis of patients. Conclusion It is of great clinical significance to establish a long-term monitoring process of PLS. In the future,it may provide true and reliable data support for the study of the influence of PLS on the prognosis of transplant patients and the correlation between PLS and multiple factors （such as patients' primary disease,immune status,age and sex of donors and recipients,blood type,etc.）. It is expected to provide a basis for improving the transplantation scheme,reducing postoperative complications and improving the success rate of transplantation.

Key words: Transplantation, Passenger lymphocytic syndrome, Monitoring, Blood transfusion