Abstract: Objective To investigate the clinical application of intrauterine transfusion therapy,and to analyze the influence of intrauterine transfusion（IUT）therapy on short-term pregnancy outcomes. Methods We retrospectively analyzed the cases who were admitted to the Guangdong Women and Children Hospital and received IUT from January 2017 to June 2021. Clinical data were divided into Fetus survival group and non-survival group based on the fetuses' condition. The reasons and frequency for IUT,gestational age at the first IUT and fetal hemoglobin concentration（Hb）,hematocrit （HCT）and peak systolic blood flow velocity of the middle cerebral artery（MCA-PSV） changes were compared between two groups. The data was statistically analyzed by SPSS 13.0 software. Results A total of 34 cases of IUT were included, of which 19 fetuses were alive and 15 were non-survivors. We performed 63 IUTs and the main causes of IUT were unexplained anemia,twin-fetal transfusion syndrome,maternal-fetal blood group incompatibility,and placental hemangioma. The Hb and HCT of the fetuses in the two groups were significantly increased,and the MCA-PSV was significantly lower after IUT（P<0.001）. Logistic regression analysis indicated that the gestational week of the first IUT （OR=1.49,P=0.041） and IUT frequency（OR=6.72,P=0.025） were protective factors for fetal survival. Conclusion IUT has a wide range of applications,which can significantly improve the fetal anemia.

Key words: Intrauterine transfusion, Anemia, Pregnancy outcome, Fetus during pregnancy