Abstract: Objective To evaluate the safety and feasibility of using a 60 g/L transfusion threshold in hemodynamically stable patients with non-variceal upper gastrointestinal bleeding based on the propensity score matching method. Methods Patients diagnosed as NVUGIB and transfused red blood cells in our hospital from January 2019 to June 2022 were selected for the study, the patients were divided into an observation group (60 g/L transfusion threshold group) and a control group (70 g/L transfusion threshold group) according to the hemoglobin concentration before transfusion. After matching with the 1:2 nearest neighbor matching, the clinical outcomes were compared between the two groups. Results After propensity score matching, 77 patients were successfully matched in the observation group and 121 patients were matched in the control group, there was no significant difference in 30-day mortality (6.5% vs. 4.1%, RR=1.234,95% CI 0.657~2.317, P=0.684) and 30-day rebleeding (7.8% vs. 11.6%, RR=0.859,95% CI 0.629~1.172, P=0.390) between the observation group and the control group in the primary clinical outcomes, the differences in lung infection rate, red blood cell consumption,the difference between Hb concentration before transfusion and after transfusion,and length of hospital stay between the two groups were not significant (P>0.05), the difference of hemoglobin concentration between the two groups after blood transfusion was significant (difference=-6.01,95% CI -7.91~-4.12, P<0.001). Conclusion The clinical outcomes of hemodynamically stable NVUGIB patients who were transfused with a 60 g/L threshold were similar to that of patients with a 70 g/L threshold, it is feasible in clinical practice.

Key words: Propensity score matching, Hemodynamically stable, Non-variceal upper gastrointestinal bleeding, Red blood cell, Transfusion threshold