Abstract: Objective To analysis the common panel cells for antibody identification in the domestic market, to study the antigen pattern, antigen coverage, and matters needing attention in analyzing and judging the identification results. Methods 20 batches of domestic panel cells (G1~G20) and 11 batches of imported panel cells (J1~J11) were collected for quality evaluation from the aspects of antigen composition pattern, antigen coverage rate, antigen negative and positive ratio and homozygote or not. The reliability of antigen was analyzed by Fisher's exact test. Results 20 batches of domestic cells were covered with 29 antigens, the coverage rate was 76.00%±34.3%, and 11 batches of imported cells were covered with 28 antigens, the coverage rate was 83.00%±21.9%. Compared the two groups of panel cells, the imported panel cells lack antigens: Mur、Di^a、Di^b、Do^a、Do^b、Yt^a、Yt^b; the domestic panel cells lack antigens: C^w、V、f、Js^a、Js^b、Xg^a; the unreliable antigen ratio of 20 batches of domestic panel cells in identifying irregular antibodies is 49.16%±7.78%, and that of 11 batches of imported panel cells is 27.61%±5.48%.The proportion of homozygotes in imported cells was 73.15%±4.59%. Conclusion The antigen coverage of domestic panel cells is similar to that of imported panel cells, but the reliability of antibody identification is significantly lower than that of imported panel cells. It is necessary to increase the number of panel cells or change the pattern of antigen composition to improve the reliability of irregular antibody identification. The imported panel cells do not contain Di^a antigen, Mur antigen and other antigens with high frequency in Chinese Han population, so they are not suitable for Chinese Han population. Because blood group antigens have ethnic and regional polymorphism, and irregular antibody distribution also has ethnic and regional polymorphism, it is suggested to design panel cells suitable for screening irregular antibody according to the ethnic concentrated areas, so as to play a greater role in clinical safe and effective blood transfusion and prevention of hemolytic disease of fetus and newborn.

Key words: Red blood cell group, Panel cells, Irregular antibody