Abstract: Objective The coagulation function of children with Kawasaki disease (KD) was tested by Century Clot (Activated Clotting Time (ACT), Platelet Function (PF), Clot Rate (CR))parameters and conventional coagulation testing (CCT). The consistency of the two detection methods were analyzed. Methods A total of 38 KD children admitted to our hospital from July 2022 to October 2022 were selected to test Century Clot, CCT and platelet count (PLT) to evaluate the coagulation function. The consistency of the two methods was compared by Kappa analysis. Results ACT (s) in subacute stage (148.50±37.18) was significantly shorter than that in acute stage (184.23±39.2), and PLT (×10⁹/L) in subacute stage (491.50±126.91) was significantly higher than that in acute stage (374.35±105.70) (both P<0.05). There was no significant difference between the two stages in other test indicators. PF values in acute stage (4.34±0.8) and subacute stage (4.21±0.92) were significantly increased compared with control group (3.54±0.89) (P<0.05). The value of CR (Condensation signal/min) in acute stage (45.03±15.99) and subacute stage (48.19±7.79) was significantly increased compared with control group (21.59±4.45) (P<0.05). Fibrinogen and D-dimer in acute and subacute stages were significantly increased (P<0.05). There was no significant difference in other indicators. The Kappa consistency analysis of Century clot and CCT showed poor coagulation function. Conclusion KD Children mainly showed hypercoagulability with increased platelet count and Fibrinogen function and content, and Fibrin cleavage products. The platelet content in subacute stage was higher than that in acute stage, and the function of coagulation factor was enhanced. The consistency of Century clot and CCT in detecting coagulation function in KD children was poor, and the two methods are irreplaceable. Combining the two methods can improve diagnosis and treatment of KD children

Key words: Kawasaki disease, Coagulation function, Century clot, Coagulation test