Serological Characteristics and Genotypes of 16 Cases with B(A) Phenotype in Nanchang Prefecture of Jiangxi Province

doi:10.3969/j.issn.1671-2587.2024.02.013

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2024, Vol. 26 ›› Issue (2): 239-243.DOI: 10.3969/j.issn.1671-2587.2024.02.013

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Serological Characteristics and Genotypes of 16 Cases with B(A) Phenotype in Nanchang Prefecture of Jiangxi Province

XU Jing¹, SHU Yi², DU Xin¹, XU Xiaoqin³

¹Nangchang Blood Center, Jiangxi 330025;
²Ji'an Blood Center, Jiangxi 343000;
³Jiujiang Vocational and Technical College, Jiangxi 332007

Received:2023-11-01 Online:2024-04-20 Published:2024-04-23

Abstract

Abstract: Objective To study the serological characteristics and genotype of B(A) phenotype in Nanchang prefecture of Jiangxi province. Methods The phenotype of AwB or AB was collected. ABO blood typing was performed by serological method on 16 highly suspected B(A) blood samples with ABO discrepancies, and family samples from 1 proband. All samples were re-examined by serological method and were subjected to sequence analysis of exons 6 and 7. Absorption-elution tests were performed to detect the reaction of B(A) samples to human anti-A. Results All 16 samples were typed as AwB and weak anti-A was found in serum. Ten samples were genotyped as ABO*BA.04 and 6 samples were ABO*BA.02. Of the 6 samples in absorption-elution tests, 4 samples with ABO*BA.04 genotype were negative, and 2 samples with ABO*BA.02 genotype showed weakly positive with human anti-A. Pedigree study showed that the ABO*BA.04 allele inherited from the father and was passed on to the son. Conclusions The serological characteristics of B(A) phenotype are similar to AwB with ABO discrepancies, so it is recommended to identify them by molecular biological methods. Different types of B(A) individuals have different A antigens on cells and reaction ability to human anti-A.

Key words: Blood group, B(A) phenotype, Serological characteristic, Genotype

CLC Number:

R457

XU Jing, SHU Yi, DU Xin, XU Xiaoqin. Serological Characteristics and Genotypes of 16 Cases with B(A) Phenotype in Nanchang Prefecture of Jiangxi Province[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2024, 26(2): 239-243.

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Serological Characteristics and Genotypes of 16 Cases with B(A) Phenotype in Nanchang Prefecture of Jiangxi Province

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