Abstract: ObjectiveTo explore the clinical significance of KDIGO standards in the patients with MODS combined with AKI for the time selection of blood purification therapy. Method150 patients with MODS/AKI were selected in our hospital who needed blood purification, and then were divided into three groups of KDIGO 1,2,3 according to the KDIGO criteria and three groups of APACHEⅡ scored <15,15 to 25,> 25 according to the APACHEⅡ criteria. The survival rate of patients in each group and the renal function improvement, average length of being hospitalized, cost of treatment and the total amount of CBP ultrafiltration treatment were respectively compared. ResultThe survival rates, renal function improvement, the average length of being hospitalized, the total cost of treatment and ultrafiltration of CBP treatment of the KDIGO1,2 patients were significantly better than patients whose APACHEⅡscore≤25 points, the difference was statistically significant(P<0.05). KDIGO3 patients’ survival rates, renal function improved survival rates, average length of stay, treatment costs and CBP treatment’s total ultrafiltration had no significant difference with patients in group of APACHEⅡscore>25(P>0.05). ConclusionThe blood purification treatment on the patients in the period of KDIGO1 and 2 can significantly improve the therapeutic effect.

Key words: KDIGO, standards, MODS, AKI, Intervention, time, of, the, blood, purification, APACHEⅡ