Abstract: Objective To analyze killer cell immunoglobulin-like receptor (KIR) gene polymorphism and genotypes characteristics in Shaanxi Han population. Methods The peripheral blood of 474 hematopoietic stem cell voluntary donors in Shaanxi were randomly collected and genotyped by polymerase chain reaction-sequence specific primer (PCR-SSP). The genotypes were designated according the Allele Frequency Net Database (AFND). Results Among Shaanxi Han population, KIR3DP1, 3DL2, 3DL3, 2DL3 and 2DL4 were found in all samples. The gene frequencies of KIR2DS4, 3DL1, 2DL1, 2DP1, 2DS3, 2DL2, 2DS2, 2DS5, 2DS1, 3DS1 and 2DL5 were 67.51%, 96.20%, 98.52%, 99.37% , 15.61%, 20.89%, 25.74%, 29.32%, 37.55%, 37.76% and 40.30% respectively. A total of 44 KIR genotypes were confirmed, among which ID1, 195, 2, 10 and 79 were the most common, with frequencies of 29.96%、13.08%、8.02%、5.91% and 5.48%,respectively. Conclusion The distribution of KIR genes and genotypes in Shaanxi Han population shows common features with Chinese Han population, and have their own distribution characteristics.

Key words: Killer cell immunoglobulin-like receptor, Gene diversity, Genotype