Genetic Polymorphism Analysis of Human Platelet Antigen 15 in Kazak Blood Donors from Urumqi,China

doi:10.3969/j.issn.1671-2587.2019.02.011

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2019, Vol. 21 ›› Issue (2): 152-154.DOI: 10.3969/j.issn.1671-2587.2019.02.011

• Orginal Article • Previous Articles Next Articles

Genetic Polymorphism Analysis of Human Platelet Antigen 15 in Kazak Blood Donors from Urumqi,China

HE Zhi

Luohe Medical College,Henan Luohe 462000

Received:2018-07-11 Online:2019-04-20 Published:2019-04-10

Abstract

Abstract: Objective To investigate the genetic polymorphism of HPA-15 alleles in Kazak blood donors from Urumqi area and to provide valuable data for clinical platelet transfusion. Method sHPA-15 system genotype was determined by PCR-SSP method in 100 Kazak blood donors from Urumqi. The frequencies of gene and genotype were calculated and compared with that in other areas. Results The frequencies of HPA-15aa,HPA-15ab and HPA-15bb in Kazak blood donors were 0.21,0.53 and 0.26,respectively. The gene frequency of HPA-15a and HPA-15b were 0.475 and 0.525,respectively. The frequencies of antigen incompatibility of HPA-15a and HPA-15b were 0.1997 and 0.1747,respectively. Conclusion The frequency of antigen incompatibility of HPA-15 is higher,which indicate HPA-15 may increase the probability of human platelet alloimmunization and may play an important role in clinical platelet transfusion.

Key words: HPA-15, Genotype, Polymorphism

CLC Number:

R457.1⁺1Q754

HE Zhi. Genetic Polymorphism Analysis of Human Platelet Antigen 15 in Kazak Blood Donors from Urumqi,China[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2019, 21(2): 152-154.

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Genetic Polymorphism Analysis of Human Platelet Antigen 15 in Kazak Blood Donors from Urumqi,China

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