Abstract: Objective To explore the effect of the washing and filtering process of intraoperative cell salvage on coagulation and fetal composition of high-risk cesarean section women, and to prove the safety of intraoperative cell salvage in the application of cesarean section. Methods Fifty high-risk women who underwent cesarean section and IOCS in the obstetrics department of a tertiary hospital were selected as the observation group, and 50 cases during the same period were selected as the control group. Maternal venous blood after delivering, pre-washing blood sample, post-washing blood sample, and filtered blood sample in observation group were collected. Fetus squamous epithelial cells, fetal red blood cells, alpha-fetoprotein and tissue factor were detected. The blood coagulation and fetal components were compared between the two groups before and after the operation. Results There was no significant difference in PT, APTT, Fib, alpha-fetoprotein and tissue factor between the two groups before and after operation (P>0.05). Compared with the blood sample before washing, the fetal red blood cells, alpha-fetoprotein and tissue factor of the blood sample after washing were significantly reduced in observation group (P<0.05). Compared with the blood sample after washing, the fetal epithelial cells, fetal red blood cell counts, alpha-fetoprotein and tissue factor of the filtered blood sample were significantly reduced (P<0.05). Conclusion Intraoperative cell salvage has little effect on maternal coagulation function. It has a good filtering effect on amniotic fluid components, high safety, and suitable for clinical application.

Key words: Intraoperative cell salvage, Cesarean section, Coagulation, Fetal composition