Abstract: ObjectiveTo Understand the incidence rate of the newborn metabolic disease and its screening condition. MethodsA retrospective analysis of newborn metabolic disease screening in Shantou for four years was done. Results25 cases were confirmed positive for congenital hypothyroidism （CH）,and incidence rate was 1/4 163. 3 cases were confirmed positive for phenylketonuria （PKU）,and incidence rate was 1/34693. 661 cases were diagnosed with Glucose-6-phosphate dehydrogenase（G6PD） deficiency,and its incidence rate was 1/158. The average screening rate of newborn metabolic disease was 30.6%,and the screen rate was going up year by year. ConclusionThe results of this study suggest the newborn screening program is beneficial for early detection and treatment of CH,PKU and G6PD deficiency. It can avoid physique and intelligent development defect of the newborns; and it also is a significance to improve population quality in our country.

Key words: Newborn, screening, Congenital, hypothyroidism, Phenylketonuria, Glucose-6-phosphate, Dehydrogenase, deficiency, Recall