Abstract: ObjectiveTo investigate the correlation between HBsAg quantitation, HBeAg and HBV DNA load detection and HBV genotyping in the positive HBeAg patients with chronic hepatitis B. MethodsThe data of 154 cases of HBeAg positive patients with chronic hepatitis B were collected, who were primarily diagnosed in an infectious disease hospital from January to December, 2014. ResultsForty-eight patients were infected with HBV genotype B , 104 with HBV genotype C and 2 with neither genytype B nor genotype C. The HBsAg level was higher [4.0 (2.6,5.5) log10IU/ml] and HBV DNA load [6.8( 4.3,8.5) log10 copies/ml] in patients infected with HBV genotype C was higher than other genotypes [4.0( 2.6,5.0) log10IU/ml, 6.5 (3.7,7.8) log10 copies/ml] (P < 0.05). However, there was no statistical significance of HBeAg level between genotype C and other genotypes. The Sperman correlation analysis showed that HBsAg had a negative correlation with HBeAg (r = -0.42, P = 0.005) or HBV DNA(r =-0.43,P = 0.03). ConclusionsCorrelation of HBsAg quantitation exists with HBeAg load, HBV DNA Level, and HBV genotypes. These markers should be jointly detected in the diagnosis of positive HBeAg patients with chronic hepatitis B.

Key words: HBsAg, HBeAg, DNA, Genotype