Alterations of Coagulation Markers in Preterm Infants with Fresh Frozen Plasma Transfusion

doi:10.3969/j.issn.1671-2587.2018.04.012

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2018, Vol. 20 ›› Issue (4): 374-376.DOI: 10.3969/j.issn.1671-2587.2018.04.012

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Alterations of Coagulation Markers in Preterm Infants with Fresh Frozen Plasma Transfusion

LIANG Xiao-liu,LIN Zheng-min,JIANG Jian-feng,et al.

Department of Blood Transfusion,the First People's Hospital of Hefei,Hefei 230061

Received:2018-02-28 Online:2018-08-20 Published:2018-08-14

Abstract

Abstract: Objective To evaluate the function of coagulation and changes of coagulation markers in the preterm infants following fresh frozen plasma transfusion. Methods Prothrombin time （PT），international normalized ratio （INR），activated partial thrombin time （APTT），fibrinogen （Fbg），thrombin time （TT），and d-dimer （DD） were examined in 71 preterm newborns and the coagulation markers were detected in 36 preterm infants who received treatments of fresh frozen plasma transfusions. Results The range of coagulation parameters were PT （16.34±3.49） s，INR 1.46±0.31，APTT （78.20±20.56） s，Fbg （1.78±0.91） g/L，TT （20.24±3.06） s，and DD （5.79±10.28） mg/L，respectively，in 71 preterm infants. The PT，INR，APTT，Fbg and DD were found to be statistically different in 36 cases of plasma transfusions （P<0.05），characterized by shortened PT and APTT，decreased INR and DD，and increased Fbg. Conclusion The reference ranges of coagulation-associated markers may differ between the preterm newborns and adults. Transfusion of fresh frozen plasma may help improve the coagulation function of the preterm infants.

Key words: Preterm infants, Coagulation function, Transfusion, Fresh frozen plasma

CLC Number:

R722.6 R457.1

LIANG Xiao-liu,LIN Zheng-min,JIANG Jian-feng,et al.. Alterations of Coagulation Markers in Preterm Infants with Fresh Frozen Plasma Transfusion[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2018, 20(4): 374-376.

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Alterations of Coagulation Markers in Preterm Infants with Fresh Frozen Plasma Transfusion

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