三种凝血功能检测方法在临床输血中的应用比较

doi:10.3969/j.issn.1671-2587.2017.04.007

临床输血与检验 ›› 2017, Vol. 19 ›› Issue (4): 336-340.DOI: 10.3969/j.issn.1671-2587.2017.04.007

三种凝血功能检测方法在临床输血中的应用比较

高晓云, 白薇, 王新华

100049 北京,航天中心医院输血科

收稿日期:2017-01-28 出版日期:2017-08-20 发布日期:2017-08-09
作者简介:高晓云（1983-）,女,甘肃古浪人,主管技师,硕士,主要从事临床输血工作,（E-mail）307806480@qq.com。

A Comparison of Three Blood Coagulation Assays in Patients with Component Transfusion

GAO Xiao-yun, BAI Wei, WANG Xin-hua

Department of Blood Transfusion,Aerospace Central Hospital. No. 15,Haidian District,Beijing City,100049

Received:2017-01-28 Online:2017-08-20 Published:2017-08-09

摘要/Abstract

摘要： 目的比较三种凝血功能检测方法对临床输血患者凝血功能评估的差异,探讨临床输血患者凝血功能评估的最佳方案。方法对60例临床申请进行血小板和/或血浆输注治疗的患者同时进行传统凝血项、血栓弹力图（thrombelastogram,TEG）、Sonoclot分析检测,分析三种方法检测凝血功能结果的相关性、一致性和差异性。结果三种方法中反映凝血因子活性的参数R、ACT、PT、APTT、INR呈明显相关;反映纤维蛋白原功能的参数ANGLE、CR、FIB明显相关;反映血小板功能的参数MA、TP、PLT显著相关。参数R与ACT、ANGLE与CR评估果存在一致性,而其他参数评估结果的一致性较差,参数TP、INR与患者临床出血现象显著相关。结论传统凝血项检测、TEG、Sonoclot检测对应参数呈显著相关,均能一定程度上反映凝血功能状况,但是三种方法检测结果的一致性较差,不能相互替代。临床输血患者凝血功能评估应综合多项检测结果并结合临床进行综合分析。

关键词: 凝血功能, 血栓弹力图, 输血

Abstract: Objective To compare the difference of three blood coagulation function assays in patients with blood component transfusion. Methods Sixty patients who had received platelets and/or plasma transfusions were selected to carry ouy routine haemostatic assays,thrombelastogram（TEG）,and Sonoclot analysis. The correlation and consistency of the three Methods were evaluated. Results A significant correlation of the R,ACT,PT,APTT and INR were observed in the three Methods. The ANGLE,CR and FIB,that reflect fibrinogen founctions,were also highly correlated,and similar correlation was noted in the MA,TP and PLT that indicate platelet founctions. Consistency of the parameters of R,ACT,and ANGLE and CR exists but the poor uniformity of the other parameters was seen. A significant correlation of TP and INR was observed with bleeding of patients. Conclusions A satisfactory correlation in routine coagulation tests,TEG and Sonoclot exists. Evaluation of coagulation founction should be based on the laboratory profile tests together with clinical menifestations of the patients.

Key words: Blood coagulation function, Thrombelastogrphy, Blood transfusion

中图分类号:

R446.11R457.1

高晓云, 白薇, 王新华. 三种凝血功能检测方法在临床输血中的应用比较[J]. 临床输血与检验, 2017, 19(4): 336-340.

GAO Xiao-yun, BAI Wei, WANG Xin-hua. A Comparison of Three Blood Coagulation Assays in Patients with Component Transfusion[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2017, 19(4): 336-340.

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三种凝血功能检测方法在临床输血中的应用比较

A Comparison of Three Blood Coagulation Assays in Patients with Component Transfusion

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