• 中国科学论文统计源期刊
  • 中国科技核心期刊
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  • 日本科学技术振兴机构数据库(JST)
临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (2): 177-179.DOI: 10.3969/j.issn.1671-2587.2019.02.018

• 临床检验 • 上一篇    下一篇

联合检测血清CXCL14、TNF-α、KL-6、SP-D在特发性肺间质纤维化诊断中的临床价值*

李莉, 危蕾, 王众福, 马伟, 刘芳英, 钱叶长   

  1. 200000 上海市宝山区中西医结合医院
  • 收稿日期:2018-04-07 出版日期:2019-04-20 发布日期:2019-04-10
  • 作者简介:李莉（1982-）,女,硕士,主治医师,主要从事肺间质疾病及慢性阻塞性肺疾病研究,（E-mail）yefan718@163.com。
  • 基金资助:
    *本课题受上海市卫计委科研项目（No.20164Y0241）资助

The Clinical Value of Serum CXCL14,TNF-α,KL-6 and SP-D in the Diagnosis of Idiopathic Pulmonary Interstitial Fibrosis

LI Li, WEI Lei, WANG Zhong-fu, et al   

  1. Department of Respiratory Disease,Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai 200000
  • Received:2018-04-07 Online:2019-04-20 Published:2019-04-10

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摘要： 目的 探讨血清CXCL14、TNF-α、KL-6、SP-D在特发性肺间质纤维化诊断中的临床价值。方法 选取某院2016年7月~2018年12月呼吸内科收治的40例特发性肺间质纤维化患者作为研究对象（研究组）,并且取同期住院的诊断为细菌性肺炎的42例患者作为对照组。采用酶联免疫吸附法测定两组患者血清中CXCL14、TNF-α、KL-6、SP-D,比较其单独检测与联合检测价值。结果 研究组四项指标均高于阈值（预定值）,对照组四项指标均低于阈值,且两组比较差异有统计学意义,P<0.05;两组在单独检测中,研究组与对照组患者四项指标阳性率比较差异有统计学意义,P<0.05;两组患者在联合检测中,研究组阳性率为90.0%,明显高于对照组阳性率14.2%,两组差异显有统计学意义,P<0.05。结论 CXCL14、TNF-α、KL-6、SP-D四项指标在特发性肺间质纤维化患者中表达程度高,四项指标联合检测能提高对特发性肺间质纤维化患者的检测结果准确性,对临床诊断有较高的价值。

关键词: 趋化因子14, 肿瘤坏死因子, II型肺泡细胞表面抗原, 肺表面活性蛋白D, 特发性肺间质纤维化, 诊断

Abstract: Objective To investigate the clinical value of serum CXCL14,TNF-α,KL-6 and SP-D in the diagnosis of idiopathic pulmonary interstitial fibrosis. Method sForty patients with idiopathic pulmonary fibrosis from January 2015 to December 2016 were selected as the study group,and 42 patients with bacterial pneumonia were enrolled in the same period. as a control group. CXCL14,TNF-α,KL-6 and SP-D were measured by enzyme-linked immunosorbent assay （ELISA）. The serum levels of CXCL14,TNF-α,KL-6 and SP-D were compared. Results The four indexes of the study group were higher than the threshold （predetermined value）,the four indicators of the control group were lower than the threshold,and the difference between the two groups was statistically significant（P<0.05）.The positive rate of the four parameters was significantly higher than that of the control group （P<0.05）in the separate test. The positive rate of the two groups was 90.0% in the combined test,which was significantly higher than that in the control group（P<0.05）. Conclusion The expression of CXCL14,TNF-α,KL-6 and SP-D in the patients with idiopathic pulmonary fibrosis is high,and the combined detection of four indicators can improve the diagnosis of idiopathic pulmonary interstitial fibers.

Key words: IL-8, TNF-α, KL-6, SP-D, Idiopathic pulmonary interstitial fibrosis, Diagnosis

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