• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)
临床输血与检验

临床输血与检验 ›› 2020, Vol. 22 ›› Issue (2): 156-160.DOI: 10.3969/j.issn.1671-2587.2020.02.011

• 临床检验 • 上一篇    下一篇

STAT3在胰腺癌辅助诊断及预后中的价值*

陈姜, 向洪洲, 李政, 张莹   

  1. 636150 四川省宣汉县人民医院肝胆外科（陈姜,向洪洲,李政）;
    贵州省人民医院肝胆外科（张莹）
  • 收稿日期:2018-11-07 出版日期:2020-04-20 发布日期:2020-04-16
  • 作者简介:陈姜（1985-）,男,四川宣汉人,主治医师,学士,主要从事胰腺疾病基础与临床工作,（Tel）15181800248。
  • 基金资助:
    *本课题受贵州省级基金资助科研项目（No.黔人社厅通477）资助

Value of STAT3 in Diagnosis and Prognosis of Pancreatic Cancer

CHEN Jiang, XIANG Hong-zhou, LI Zheng, et al   

  1. Department of Hepatobiliary Surgery, Xuanhan People's Hospital, Xuanhan, Sichuan 636150
  • Received:2018-11-07 Online:2020-04-20 Published:2020-04-16

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摘要： 目的 分析信号传导及转录激活蛋白3（signal transducer and activator of transcription3, STAT3）在胰腺癌辅助诊断及预后的价值。方法 于2014年2月~2016年8月,收集医院肝胆外科已行手术的胰腺癌患者74例,良性胰腺肿瘤、胰腺炎80例（各40例）。对样本进行免疫组化分析,对比胰腺癌、良性疾病对象的STAT3表达,评价STAT3表达诊断效用。分析STAT3阳性、阴性对象的胰腺癌分期、淋巴结转移情况。以24个月为观察期,对比胰腺癌预后不良（出现扩散、转移、复发）对象32例、预后良好胰腺癌对象42例的STAT3。结果 胰腺癌组织STAT3表达率高于癌旁组织、癌旁组织高于良性胰腺疾病,差异有统计学意义（P<0.05）。胰腺癌组织、癌旁组织、良性胰腺组织中的p-STAT3表达水平差异有统计学意义（P<0.05）。STAT3诊断胰腺癌的灵敏度、特异度、阳性预测值、阴性预测值、符合率分别为70.3%（52/74）、86.2%（69/80）、82.5%（52/63）、75.8%（69/91）、78.6%（121/154）。胰腺癌组织中STAT3阳性的对象淋巴结转移高于STAT3阴性对象,胰腺癌组织中STAT3阳性的对象临床分期与STAT3阴性对象差异有统计计学意义（P<0.05）。胰腺癌预后不良对象组织中STAT3阳性率高于胰腺癌预后良好的,差异有统计学意义（P<0.05）。结论 STAT3在胰腺癌辅助诊断及预后预测中具有一定的应用价值。

关键词: 胰腺癌, 进展, 信号传导及转录激活蛋白3, 诊断

Abstract: Objective To analyze the value of signal transducer and activator of transcription 33 in diagnosis and prognosis of pancreatic cancer. Methods From February 2014 to August 2016, specimens from 74 cases of pancreatic cancer, 80 cases of benign pancreatic tumor and pancreatitis （40 cases each） were collected. The expression level of STAT3 in pancreatic cancer and benign disease was detected by immunohistochemical staining, then compared to evaluate the diagnostic efficacy of STAT3 expression. The staging and lymph node metastasis of pancreatic cancer in STAT3 positive and negative subjects were analyzed. STAT3 was compared between 32 patients with poor prognosis （spread, metastasis, recurrence） and 42 patients with good prognosis. Results The expression of STAT3 in pancreatic cancer was higher than that in adjacent tissues, and the difference was statistically significant （P<0.05）. There was significant difference in the expression of p-STAT3 in pancreatic carcinoma tissues, paracancerous tissues and benign pancreatic tissues （P<0. 05）.The sensitivity, specificity, positive predictive value, negative predictive value and coincidence rate of STAT3 in the diagnosis of pancreatic cancer were 70.3% （52/74）, 86.2% （69/80）, 82.5% （52/63）, 75.8% （69/91） and 78.6% （121/154）, respectively. The lymph node metastasis of STAT3 positive pancreatic cancer was higher than that of STAT3 negative pancreatic cancer. STAT3 positive lymph node metastasis in pancreatic carcinoma was higher than that in STAT3 negative group. The clinical stages of STAT3 positive patients in pancreatic carcinoma were statistically different from STAT3 negative ones （P<0. 05）. The positive rate of STAT3 in patients with poor prognosis was significantly higher than that in patients with good prognosis （P<0. 05）. Conclusion STAT3 is valuable in the diagnosis of pancreatic cancer and the prediction of growth and metastasis.

Key words: Pancreatic cancer, Progress, STAT3, Diagnosis

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