关键词: 超敏C反应蛋白, 颈动脉狭窄, 颈动脉支架植入术, 再狭窄预测价值

Abstract: Objective To investigate the relationship between serum hypersensitive C-reactive protein （hs-CRP） and carotid artery stenosis and restenosis after carotid artery stenting （CAS）,so as to provide references for its clinical application. Method sOne hundred and sixty-eight patients undergoing CAS were selected in the hospital. The level of serum hs-CRP of pre-operation and 1d,7d,3 mon and 6 mon post-operation was measured. The relationship was analyzed between serum hs-CRP level and the degree of stenosis and restenosis following CAS. Results The incidence of carotid stenosis increased with the level of serum hs-CRP （P<0.05） before operation. The incidence of restenosis was 19.05% （32/168） after 6 months of operation. No difference of the serum hs-CRP level was noted at pre-operation and 1d post-operation between the patients of restenosis and non-restenosis （P>0.05）. The serum hs-CRP level in the patients of restenosis was significantly higher than that in those of non-restenosis on 7 d,3 mon and 6 mon post-operation,while the patients of non-restenosis had a higher level of △hs-CRP than those of restenosis （P<0.05）. The serum hs-CRP level in all the patients increased significantly on day 1 after surgery,and it remained a high level after 7d of surgery in the patients of restenosis compared with those of pre-operation. However,the hs-CRP level was significantly decreased in the patients of no-restenosis （P<0.05）. Multivariate regression analysis showed that △hs-CRP was an independent risk factor for restenosis after CAS. Conclusion The remarkable increase of serum hs-CRP was positively associated with the carotid stenosis following CAS,suggesting a predict marker for carotid artery restenosis.

Key words: Hypersensitive C-reactive protein, Carotid artery stenosis, Carotid artery stenting, Restenosis predictive value