• 中国科学论文统计源期刊
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临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (2): 187-190.DOI: 10.3969/j.issn.1671-2587.2019.02.021

• 临床检验 • 上一篇    下一篇

老年SAP患者外周血T淋巴细胞亚群、血清PCT及hs-CRP水平变化的临床探析*

陈劲松, 王丽娜   

  1. 225002 扬州友好医院检验科（陈劲松）; 盐城市第三人民医院神经内科（王丽娜）
  • 收稿日期:2018-11-27 出版日期:2019-04-20 发布日期:2019-04-10
  • 作者简介:陈劲松（1972-）,男,江苏扬州人,副主任技师,学士,主要从事临床微生物和免疫工作,（Tel）13625211945（E-mail）hjgfdcv@163.com。
  • 基金资助:
    * 本课题受盐城市科技计划项目（No.YK2015122）资助

Clinical Analysis of Changes of Peripheral Blood T-lymphocyte Subsets, Serum PCT and Hs-CRP Levels in Elderly Patients with SAP

CHEN Jin-song, WANG Li-na   

  1. Department of clinical laboratory, Yangzhou Friendship Hospital,Jiangsu 225002
  • Received:2018-11-27 Online:2019-04-20 Published:2019-04-10

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摘要： 目的 探讨老年卒中相关性肺炎（SAP）患者外周血T淋巴细胞亚群、血清降钙素原（PCT）和高敏-C反应蛋白（hs-CRP）水平变化。方法 将2017年2月~2018年2月本院收治的24 h内发病入院的老年卒中患者59例作为观察组,1周内发生SAP的患者35例纳入A组,未发生SAP的患者24例纳入B组;再将同期来本院进行健康体检者45例作为对照组。检测各组外周血T淋巴细胞亚群、血清PCT和hs-CRP水平,并进行对比分析。结果 A、B组CD3+、CD4+、CD4+/CD8+水平均低于对照组,CD8+水平高于对照组,差异有统计学意义（P<0.05）;A组CD4+/CD8+水平低于B组,差异有统计学意义（P<0.05）;A、B组血清PCT、hs-CRP水平均高于对照组,差异有统计学意义（P<0.05）;A组血清PCT、hs-CRP水平均高于B组,差异有统计学意义（P<0.05）。结论 老年SAP患者发病初期细胞免疫功能水平较低,血清PCT、hs-CRP水平较高,血清PCT和hs-CRP对于检验早期卒中相关性肺炎具有显著临床价值。

关键词: 老年, 卒中相关性肺炎, 外周血T淋巴细胞亚群, 血清降钙素原, 高敏-C反应蛋白

Abstract: Objective To investigate the changes of peripheral blood T-lymphocyte subsets, serum procalcitonin (PCT) and high-sensitivity-C-reactive protein (hs-CRP) levels in elderly patients with stroke-associated pneumonia (SAP). Method sFifty-nine patients with senile stroke admitted to hospital within 24 hours from February 2017 to February 2018 in our hospital were selected as study subjects. 35 patients with SAP within 1 week were included in group A, and 24 patients without SAP were included in group B in this study; 45 cases of physical examination in our hospital at the same period were used as control group. Peripheral blood T lymphocyte subsets, serum PCT and hs-CRP levels were measured and compared. Results The levels of CD3+, CD4+, and CD4+/CD8+ in group A and B were lower than those in control group. The level of CD8+ was higher than that in control group (P<0.05). The ratio of CD4+/CD8+ in group A was lower than that in group B (P<0.05); Serum PCT and hs-CRP levels in group A and B were significantly higher than those in control group (P<0.05); Serum PCT and hs-CRP levels were higher in group A than in group B, the difference was statistically significant (P<0.05). Conclusion sThe elderly patients with SAP have lower levels of cellular immune function at the early onset, and serum PCT and hs-CRP levels are higher. Serum PCT and hs-CRP show significant clinical value for the detection of early stroke-associated pneumonia

Key words: Elderly, SAP, Peripheral blood T lymphocyte subsets, Serum PCT, hs-CRP

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