慢性阻塞性肺疾病患者血清Galectin-3、IL-38水平与肺功能相关性研究

doi:10.3969/j.issn.1671-2587.2020.02.010

临床输血与检验 ›› 2020, Vol. 22 ›› Issue (2): 152-156.DOI: 10.3969/j.issn.1671-2587.2020.02.010

慢性阻塞性肺疾病患者血清Galectin-3、IL-38水平与肺功能相关性研究

杜维桓, 纪红, 李德善, 严之红, 朱娅丽, 杜左萍

100049 北京,航天中心医院老年医学二科

收稿日期:2018-11-26 出版日期:2020-04-20 发布日期:2020-04-16
通讯作者: 纪红,女,主任医师,主要从事老年呼吸系统疾病研究,（Tel）010-59972053。
作者简介:杜维桓（1979-）,男,山西太谷人,主治医师,硕士,主要从事老年呼吸系统疾病研究,（Tel）13671319595。

Correlation Analysis of Serum Galectin-3, IL-38 Levels with Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease

DU Wei-huan, JI Hong, LI De-shan, et al

Department of Geriatric Medicine,Aerospace Center Hospital,Beijing 10004

Received:2018-11-26 Online:2020-04-20 Published:2020-04-16

摘要/Abstract

摘要： 目的探讨慢性阻塞性肺疾病患者血清半乳糖凝集素-3（Galectin-3）、白介素-38（IL-38）水平变化及与肺功能的相关性。方法选取本院2016年1月~2018年4月诊治的258例慢性阻塞性肺疾病患者为观察组,其中急性加重期患者（急性组）151例,稳定期患者（稳定组）107例;选取同期129例健康体检者为对照组。入组时检测研究对象血清Galectin-3、IL-38、CRP、PCT水平及肺功能,分析血清Galectin-3、IL-38、CRP、PCT水平与肺功能的相关性。应用ROC曲线分析血清Galectin-3、IL-38、PCT水平对慢性阻塞性肺疾病急性加重期的诊断价值。结果急性组和稳定组患者血清Galectin-3、IL-38、CRP、PCT水平均高于对照组（P<0.05）,且急性组高于稳定组（P<0.05）;急性组和稳定组患者PEF% pred、FEV1% pred及FEV1/FVC水平均低于对照组（P<0.05）,且急性组低于稳定组（P<0.05）。血清Galectin-3、IL-38、CRP、PCT水平与肺功能指标（PEF% perd、FEV1% pred、FEV1/FVC）呈负相关。ROC曲线分析显示,血清Galectin-3、IL-38诊断COPD急性加重期的曲线下面积（AUC）分别为0.839、0.893,敏感度分别为0.808、0.781,特异度分别为0.841、0.748。血清Galectin-3、IL-38诊断COPD急性加重期的AUC、灵敏度和特异度均高于CRP（AUC：0.735,灵敏度：0722,特异度：0.710）和PCT（AUC：0.760,灵敏度：0.702,特异度：0.682）。结论 COPD患者血清Galectin-3、IL-38、CRP、PCT水平显著上升,并且与肺功能存在一定的关系,可作为COPD患者病情判断的标志物;但血清Galectin-3、IL-38在COPD急性加重期的诊断价值优于CRP和PCT。

关键词: 慢性阻塞性肺疾病, 半乳糖凝集素-3, 白介素-38, 肺功能, 临床价值

Abstract: Objective To investigate the changes of serum galectin-3 and IL-38 levels in patients with chronic obstructive pulmonary disease （COPD） and their correlation with pulmonary function. Methods From January 2016 to April 2018,151 patients with acute exacerbation of COPD were selected as acute group, 107 stable COPD patients and 129 healthy people in the same period were selected as stable group and control group. Serum Galectin-3,IL-38,CRP and PCT levels and lung function were measured at the time of enrollment. Pearson correlation was used to analyze the correlation among serum Galectin-3,IL-38,CRP and PCT levels and lung function. Results The serum levels of Galectin-3,IL-38,CRP and PCT were higher in acute group and stable group than in control group （P<0.05）. The serum levels of Galectin-3,IL-38,CRP and PCT in acute group were higher than those in the stable group （P<0.05）. The levels of PEF% pred, FEV1% pred and FEV1/FVC in acute group and stable group were lower than those of in control group （P<0.05）,and the levels of PEF% pred, FEV1% pred and FEV1/FVC in acute group were lower than those in stable group（P<0.05）. Serum Galectin-3,IL-38,CRP and PCT levels were negatively correlated with pulmonary function indices （PEF% perd, FEV1% pred,FEV1/FVC,P<0.05）. ROC curve analysis showed that the area under curve （AUC） of serum Galectin-3 and IL-38 in the diagnosis of acute exacerbation of COPD was 0.839 and 0.893, the sensitivity was 0.808 and 0.781, and the specificity was respectively 0.841 and 0.748. The AUC,sensitivity and specificity of serum Galectin-3 and IL-38 in the diagnosis of acute exacerbation of COPD were higher than those of CRP （AUC: 0.735, sensitivity: 0.722, specificity:0.710） and PCT （AUC:0.760, sensitivity: 0.702, specificity:0.682）. Conclusion Serum Galectin-3 and IL-38 levels increased significantly in COPD patients, which were closely related to lung function. And serum Galectin-3 and IL-38 could be used as a biological marker for estimating the severity of COPD. However, the diagnostic value of serum Galectin-3 and IL-38 in acute exacerbation of COPD are better than that of CRP and PCT.

Key words: Chronic obstructive pulmonary disease, Galectin-3, Interleukins-38, Pulmonary function, Clinical value

中图分类号:

R563.9

杜维桓, 纪红, 李德善, 严之红, 朱娅丽, 杜左萍. 慢性阻塞性肺疾病患者血清Galectin-3、IL-38水平与肺功能相关性研究[J]. 临床输血与检验, 2020, 22(2): 152-156.

DU Wei-huan, JI Hong, LI De-shan, et al. Correlation Analysis of Serum Galectin-3, IL-38 Levels with Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2020, 22(2): 152-156.

参考文献

1 Yao C Y，Liu X L，Tang Z. Prognostic role of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio for hospital mortality in patients with AECOPD[J]. Int J Chron Obstruct Pulmon Dis，2017，12：2285-2290.
2 段玉香，范晔，杨海峰，等. 慢性阻塞性肺疾病急性加重期患者肺部真菌感染对血清炎症因子的影响[J]. 中华医院感染学杂志，2017，27（4）：754-757.
3 Wang W Q，Ying Y Y，Wu Q Y，et al. A GIS-based spatial correlation analysis for ambient air pollution and AECOPD hospitalizations in Jinan，China[J]. Respir Med，2015，109（3）：372-378.
4 Mutlu L C，Altintas N，Aydin M，et al. Growth Differentiation Factor-15 Is a Novel Biomarker Predicting Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J]. Inflammation，2015，38（5）：1805-1813.
5 Farnworth S L，Henderson N C，Mackinnon A C，et al. Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function[J]. Am J Pathol，2008，172（2）： 395-405.
6 Riccio A M，Mauri P，De Ferrari L，et al. Galectin-3：an early predictive biomarker of modulation of airway remodeling in patients with severe asthma treated with omalizumab for 36 months[J]. Clin Transl Allergy，2017，7：6.
7 Xu W D，Huang A F. Role of interleukin-38 in chronic inflammatory diseases：a comprehensive review[J]. front immunol，2018，9：1462.
8 Attia G A.Correlation of respiratory pump function with symptomatology in COPD[J]. Egypt J Chest Dis Tuberc，2016，65（1）：35-40.
9 Barbu C，Iordache M，Man M G. Inflammation in COPD：pathogenesis，local and systemic effects[J]. Rom J Morphol Embryol，2011，52（1）：21-27.
10 Austin V，Crack P J，Bozinovski S，et al. COPD and stroke：are systemic inflammation and oxidative stress the missing links?[J]. Clin Sci（Lond），2016，130（13）：1039-1050.
11 Pilette C，Colinet B，Kiss R，et al. Increased galectin-3 expression and intra-epithelial neutrophils in small airways in severe COPD[J]. Eur Respir J，2007，29（5）：914-922.
12 岳曼，朱磊，李军. IL-38通过上调CXCL1及IL-8募集中性粒细胞促进转移病灶的形成研究[J]. 中国免疫学杂志，2018，34（7）：1070-1074.
13 Feng W，Wu X J，Li S，et al. Association of serum galectin-3 with the acute exacerbation of chronic obstructive pulmonary disease[J]. Med Sci Monit，2017，23：4612-4618.
14 Agoston-Coldea L，Lupu S，Petrovai D，et al. Correlations between echocardiographic parameters of right ventricular dysfunction and Galectin-3 in patients with chronic obstructive pulmonary disease and pulmonary hypertension[J]. Med Ultrason，2015，17（4）：487-495.
15 朱亚茜，马淑萍，李波，等. 白细胞介素38在慢性阻塞性肺疾病患者血清中的表达及临床意义[J]. 中华医学杂志，2018，98（10）：759-762.
16 杨继雷，姚秀叶，袁晓飞，等. 慢性阻塞性肺疾病患者血清NE、α1-AT、CRP、PCT的表达及与肺功能的关系研究[J]. 现代生物医学进展，2018，18（15）：2966-2969.
17 Machin M，Amaral A F，Wielscher M，et al. Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies[J]. BMC Pulm Med，2017，17（1）：54.
18 Sterk P J. Chronic diseases like asthma and COPD： do they truly exist?[J]. Eur Respir J，2016，47（2）：359-361.
19 Ho J E，Gao W，Levy D，et al. Galectin-3 is associated with restrictive lung disease and interstitial lung abnormalities[J]. Am J Respir Crit Care Med，2016，194（1）：77-83.
20 蒋鲲，陆小霞，王莹，等. 哮喘患儿血清25（OH）D3水平与血清及支气管肺泡灌洗液中半乳糖凝集素-3水平的关系[J]. 中国当代儿科杂志，2015，17（12）：1301-1305.
21 Pouwels S D，Hesse L，Faiz A，et al.Susceptibility for cigarette smoke-induced DAMP release and DAMP-induced inflammation in COPD[J]. Am J Physiol Lung Cell Mol Physiol，2016，311（5）：881-892.
22 何小双，许西琳，刘冬，等.慢性阻塞性肺疾病患者呼出气冷凝液中白介素8、白介素17水平及其与第1秒用力呼气末容积占预计值百分比的关系研究[J]. 中国全科医学，2016，19（1）：63-67.
23 Yuan X，Peng X，Li Y，et al. Role of IL-38 and its related cytokines in inflammation[J]. Mediators Inflamm，2015，2015：807976.

[1]	何雯, 毕良学, 王宁玲. 支气管哮喘患儿白介素、TNF-α与肺功能及免疫功能的关系研究[J]. 临床输血与检验, 2020, 22(6): 638-642.
[2]	程继勇, 谭家明, 李军文. 低分子肝素治疗AECOPD合并呼吸衰竭的疗效、凝血指标、CK-MB及炎性因子表达的临床观察[J]. 临床输血与检验, 2020, 22(2): 172-176.
[3]	朱峥, 成青, 吴要华, 孙妍, 周奇兴. OSTA在老年慢性阻塞性肺疾病患者骨健康评估中的应用^*[J]. 临床输血与检验, 2019, 21(1): 59-61.
[4]	冯晓鸿, 陆正民, 杜合娟. 血清补体C3和C4检测对自身免疫性肝炎患者病情评估的价值^*[J]. 临床输血与检验, 2019, 21(1): 62-64.
[5]	孙莹, 刘长春, 郝丽梅, 王佳, 王春玲. RDW、Cys-C与慢性阻塞性肺疾病患者继发肺动脉高压关系的研究[J]. 临床输血与检验, 2018, 20(5): 531-533.
[6]	王伟, 葛亮, 居朝霞. 抗-HCV-IgG 抗体及血清HCV RNA在丙型肝炎诊断中的应用价值^*[J]. 临床输血与检验, 2017, 19(6): 602-605.
[7]	陆正民, 冯晓鸿, 杜合娟. 血清5′-NT、TBA 与MAO检测对肝肿瘤的诊断价值^*[J]. 临床输血与检验, 2017, 19(6): 605-608.
[8]	孙峰, 张静, 张永娟, 梅倩, 昝丽娜, 刘广印. 慢性阻塞性肺疾病急性加重患者中病原体的检测分析[J]. 临床输血与检验, 2017, 19(2): 162-166.

慢性阻塞性肺疾病患者血清Galectin-3、IL-38水平与肺功能相关性研究

Correlation Analysis of Serum Galectin-3, IL-38 Levels with Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 8

编辑推荐

Metrics

本文评价

关于本刊

作者中心

在线期刊

访问统计

联系我们