• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)
临床输血与检验

临床输血与检验 ›› 2020, Vol. 22 ›› Issue (4): 360-366.DOI: 10.3969/j.issn.1671-2587.2020.04.006

• 新型冠状病毒肺炎专题（二） • 上一篇    下一篇

80例新型冠状病毒感染肺炎患者相关血液检测指标分析

王云, 赵长城, 谷妍, 姚余有, 刘杨, 岳莉, 石玉如, 查晓丹, 戚应杰   

  1. 230022 合肥, 中国科学技术大学附属第一医院（安徽省立医院感染病院）（王云, 赵长城, 谷妍, 刘杨, 岳莉, 石玉如, 查晓丹, 戚应杰）;
    安徽医科大学公共卫生学院 （姚余有）
  • 收稿日期:2020-03-04 出版日期:2020-08-20 发布日期:2020-08-12
  • 通讯作者: 戚应杰, 男, 主任检验师, 主要从事感染性疾病的实验室诊断与研究, （E-mail）7yingjie@sina.com。
  • 作者简介:王云（1982-）, 女, 安徽合肥人, 主管检验师, 硕士, 主要从事感染性疾病的检测与研究, （E-mail）54126143@qq.com。

Analysis of Novel Coronavirus Pneumonia Related Blood Test Indexes in 80 Cases

WANG Yun, ZHAO Chang-cheng, GU Yan, et al.   

  1. The First Affiliated Hospital of University of Science and Technology of China （Anhui provincial hospital infection hospital） Hefei Anhui 230022
  • Received:2020-03-04 Online:2020-08-20 Published:2020-08-12

PDF

3240

摘要： 目的 研究新型冠状病毒感染肺炎患者实验室检测指标变化的情况及其临床意义, 为临床诊断、治疗提供科学参考依据。方法 回顾性分析本院在2020年收治的80例新冠肺炎确诊患者的相关血液检测指标, 将健康体检者分为A组（n=40例）, 疑似新型冠状病毒感染的肺炎患者分为B组（n=40例）, 确诊为新型冠状病毒感染的肺炎患者分为C组（n=80例）, 比较三组人群的实验室血常规、T 淋巴细胞亚群免疫分型及生化等指标的变化水平。结果 确诊组C组WBC、L（%）、RBC、HGB、CD3+、CD4+、CD8+、BUN、UA均低于健康组A组, 差异均有统计学意义（P<0.05）;确诊组C组G（%）、hs-CRP、ALT、AST、TB、DB、SAA、LDH、CK-MB均高于健康组A组, 差异均有统计学意义（P<0.05）。确诊组C组CD4+、TnI均低于疑似组B组, 差异均有统计学意义（P<0.05）;确诊组C组AST、SAA、LDH 、CK-MB均高于疑似组B组, 差异均有统计学意义（P<0.05）;三组之间PLT、CD4+/ CD8+、CR、CYC、PCT、MYO、CK等项目差异均无统计学意义（P>0.05）。多因素二元logistic逐步回归分析显示, SAA、CK-MB、LDH、AST、TB、DB越高, 患新冠肺炎的危险性越大;WBC、L%、HGB、BUN、UA、CD4+、CD8+ 越低, 患新冠肺炎的危险性也越大。结论 新型冠状病毒肺炎患者的各项实验室指标有明显变化, 对于病毒感染的早期诊断和治疗具有较强的参考价值, 是对核酸金标准的有效补充, 应予以重视。

关键词: 新型冠状病毒, 新型冠状病毒肺炎, 实验室指标

Abstract: Objective To study the changes of laboratory test indexes of pneumonia patients infected by novel coronavirus and its clinical significance to provide scientific reference for clinical diagnosis and treatment. Methods The relevant blood test indexes of 80 patients with new diagnosed novel coronavirus pneumonia admitted to our hospital in 2020 were retrospectively analyzed. Normal physical examination subjects were enrolled as Group A （n=40 cases）, patients with pneumonia suspected of novel coronavirus infection were Group B （n=40 cases） and patients with pneumonia diagnosed as novel coronavirus infection were Group C（n=80 cases）. The changes of laboratory blood routine, T lymphocyte subgroup and biochemical parameters in the three groups were compared. Results Compared with normal group A, WBC, L（%）, RBC, HGB, CD3+, CD4+, CD8+, BUN, UA, in confirmed group C were lower than those in normal group A, with statistical difference（P<0.05）;while G（%）, hs-CRP, ALT, AST, TB, DB, SAA, LDH, CK-MB in confirmed group C were higher than those in normal group A, with statistical difference（P<0.05）.Compared with suspected group B, CD4+、TnI are lower in confirmed group C than that in suspected group B, AST, SAA, LDH, CK-MB in confirmed group C are higher than those in suspected group B with statistical difference（P<0.05）. There was no significant difference in PLT, CD4+/CD8+, CR, CYC, PCT, MYO, CK among the three groups（P>0.05）. Multivariate logistic stepwise regression analysis showed that the higher are in SAA, CK-MB, LDH, AST\TB, DB, the greater is the risk of novel coronavirus pneumonia; The lower are in the WBC, L%, HGB, BUN, UA, CD4+, CD8+, the greater is the risk of novel coronavirus pneumonia. Conclusion The changes of various laboratory indexes in patients infected by novel coronavirus have obvious significance. These indexes have certain reference value for the early diagnosis and treatment of novel coronavirus.It is an effective supplement to nucleic acid test（a gold standard method）, which is helpful for clinical diagnosis of novel coronavirus pneumonia.

Key words: SARS-CoV-2, COVID-19, Laboratory, indicators

中图分类号: