• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)
临床输血与检验

临床输血与检验 ›› 2021, Vol. 23 ›› Issue (4): 450-454.DOI: 10.3969/j.issn.1671-2587.2021.04.009

• 临床输血 • 上一篇    下一篇

1周岁内婴幼儿月龄与ABO血型抗体凝集强度消长的多中心前瞻性研究*

李志强, 吕先萍, 刘铁梅, 刘冰, 张冬霞, 宫济武, 马曙轩, 刘莹, 陈剑, 黄吉娥, 吕孟兴, 罗冰, 文军, 柳美秀, 李兴龙, 李丽玮, 于建   

  1. 200233 上海,上海交通大学附属第六人民医院（李志强,李兴龙,李丽玮,于建 ）; 郑州大学第一附属医院（吕先萍）; 吉林大学中日联谊医院（刘铁梅）; 吉林大学第一医院（刘冰）; 吉林省肿瘤医院（张冬霞）; 北京医院（宫济武）; 北京市儿童医院（马曙轩）; 宝鸡市妇幼保健院（刘莹）; 四川大学华西二院（陈剑）; 贵州医学院附属医院（黄吉娥）; 昆明市儿童医院（吕孟兴）; 广州医学院附属第三医院（罗冰）; 新疆维吾尔自治区人民医院（文军）; 复旦大学医学院附属儿科医院（柳美秀）
  • 收稿日期:2020-11-20 出版日期:2021-08-20 发布日期:2021-08-18
  • 作者简介:李志强（1962-）,男,上海人,主任医师,硕士研究生导师,主要从事血液系统疾病诊治与临床输血不良反应研究,（E-mail）kcb039@126.com。
  • 基金资助:
    *本课题受中国输血协会威高科研基金项目（No.CSBT-WG-2018-06）、第四轮（2016-2018年）上海市公共卫生重点建设项目《输血医学》（No.15GWZK0501）、上海市科学技术委员会科研计划项目（No.17DZ2200800）资助

A Prospective Multi-center Study on the Relationship between the Age and the Agglutination Intensity of Anti-A/B Antibody in Infants within One Year of Age

LI Zhi-qiang, LV Xian-ping, LIU Tie-mei, et al   

  1. Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233
  • Received:2020-11-20 Online:2021-08-20 Published:2021-08-18

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摘要： 目的 多中心前瞻性研究1周岁婴幼儿红细胞ABO血型抗体凝集强度与月龄消长的相关性。方法 1周岁内婴幼儿1 564名按月龄分成12组,应用常温试管法、4 ℃试管法、微柱凝集法检测ABO血型反定型。结果 应用4 ℃试管法和微柱凝集法进行ABO血型反定型检测时,其凝集强度评分≥4分（凝集≥1+W）,月龄≥6个月;其凝集强度评分≥7分（凝集≥2+W）,月龄≥9个月。应用常温试管法进行ABO血型反定型检测时,其凝集强度评分≥4分（凝集≥1+W）,月龄≥8个月;其凝集强度评分≥7分（凝集≥2+W）,月龄≥10个月。另外,1月龄时,相比 B型反定型A细胞、A型反定型B细胞的凝集强度,O型婴幼儿反定型A、B细胞凝集强度高,但随着月龄增加至4月龄时O型反定型A、B细胞凝集强度降到最低,之后又逐渐增高。结论 明确国内1周岁内婴幼儿红细胞ABO血型反定型检测时间与结果强度判断的界定值。

关键词: 婴幼儿, ABO血型, 反定型, 抗体

Abstract: Objective A prospective multi-center study was conducted to investigate the correlation between agglutination intensity of Anti-A/B antibody and age in infants <1 year of age. Methods 1 564 infants were divided into 12 groups by age. The ABO reverse typing was respectively detected by tube method at room temperature and at 4℃ and microcolumn gel method. Results Considering the results of reverse typing by tube method at 4 ℃ and microcolumn gel method, it showed that agglutination score ≥ 4 points （agglutination ≥ 1+W） in the infants age ≥6 months and that agglutination score ≥7 points （agglutination ≥2+W） in the infants age ≥ 9 months. Considering the results of reverse grouping by test tube method at room temperature, it showed that the agglutination score ≥4 points （agglutination ≥1+W） in the infants age ≥ 8 months, and that the agglutination score ≥7 points （agglutination ≥2+W） in the infants age ≥ 10 months. In addition, the agglutination scores （A cell and B cell） of group O infants at 1-month old were higher than group B infants （A cells） and group A infants （B cell） respectively in reverse grouping. In regards of group O infants, the agglutination scores of A cells and B cells reached to the nadir at the age of 4 months, then gradually increased. Conclusion We recommended the detection time and agglutination intensity value of ABO reverse typing in Chinese infants within 1 year old.

Key words: Infant, ABO blood group, Reverse typing, Antibody

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