低氧诱导因子HIF-2α调控红细胞生成的研究进展*

doi:10.3969/j.issn.1671-2587.2021.05.004

临床输血与检验 ›› 2021, Vol. 23 ›› Issue (5): 561-564.DOI: 10.3969/j.issn.1671-2587.2021.05.004

低氧诱导因子HIF-2α调控红细胞生成的研究进展*

高瞻, 肖军, 李小薇, 李翠莹

100142 空军特色医学中心输血科（高瞻,肖军,李小薇,李翠莹）; 安徽医科大学空军特色医学中心临床学院（高瞻）

收稿日期:2021-04-07 出版日期:2021-10-20 发布日期:2021-10-20
通讯作者: 李翠莹,女,主任技师,硕士研究生导师,主要从事临床输血及高原输血研究,（E-mail）licuiying2013@qq.com。
作者简介:高瞻（1997-）,男,四川西昌人,硕士研究生在读,主要从事临床检验诊断学方面研究,（E-mail）693454231@qq.com。
基金资助:
*本课题受国家自然科学基金（No.81971778）资助

Received:2021-04-07 Online:2021-10-20 Published:2021-10-20

摘要/Abstract

摘要： 氧气（O₂）是有氧生物生存的必需品,在低氧条件下细胞激活许多适应性反应使O₂供应满足生物代谢、能量和氧化还原需求,其中红细胞生成增加就是全身缺氧典型反应之一。低氧诱导因子（hypoxia inducible factors,HIFs）是低氧应激调控机制的核心,由功能亚单位α亚基（包括1α、2α、3α）和结构亚单位β亚基构成。研究表明,HIF-2α是调控红细胞生成的主要HIFs,这不仅源于其最重要的靶基因-促红细胞生成素是红细胞成熟的关键因子,也因其对造血器官正常发育以及机体铁代谢平衡维持具有重要意义。本文将从上述方面对HIF-2α调控红细胞生成的研究进行梳理和阐述。

关键词: 低氧诱导因子2α, 造血干细胞, 促红细胞生成素, 铁代谢

中图分类号:

R331.1⁺41

高瞻, 肖军, 李小薇, 李翠莹. 低氧诱导因子HIF-2α调控红细胞生成的研究进展*[J]. 临床输血与检验, 2021, 23(5): 561-564.

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低氧诱导因子HIF-2α调控红细胞生成的研究进展*

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