极低出生体重儿贫血相关因素及评估模型建立*

doi:10.3969/j.issn.1671-2587.2022.02.013

临床输血与检验 ›› 2022, Vol. 24 ›› Issue (2): 202-206.DOI: 10.3969/j.issn.1671-2587.2022.02.013

极低出生体重儿贫血相关因素及评估模型建立^*

赵兴丹, 符小玲, 翁艾罕

570206 海南海口,海南省妇女儿童医学中心

收稿日期:2021-09-28 发布日期:2022-04-12
作者简介:赵兴丹（1987-）,女,海南东方人,主管技师,学士,主要从事临床输血相关研究,（E-mail） douqi15333@163.com。
基金资助:
*本课题受海南省临床医学中心建设项目（琼卫医函[2021]75号）资助

Anemia-Related Factors in Very Low Birth Weight Infants and Establishment of an Assessment Model

ZHAO Xing-dan, FU Xiao-ling, WENG Ai-han

Department of Blood Transfusion,Hainan Women and Children's Medical Center,Haikou 570206

Received:2021-09-28 Published:2022-04-12

摘要/Abstract

摘要： 目的探究极低出生体重儿（very low birth weight infant,VLBWI）贫血的相关因素,并建立列线图预测模型。方法回顾性选取2016年1月~2021年7月我院新生儿科及NICU收治的VLBWI为研究对象,记录其一般资料、产前资料、产后资料及住院期间并发症发生情况,根据是否贫血,将研究对象分为贫血组（73例）和非贫血组（81例）。采用二分类Logistic回归分析筛选VLBWI贫血的危险因素;建立列线图预测模型,并采用ROC曲线评估列线图模型对VLBWI贫血的预测能力。结果多因素Logistic回归结果显示出生体重、出生胎龄、出生时血红蛋白（hemoglobin,Hb）、出生时红细胞比容（hematocrit,Hct）、出生时网织红细胞血红蛋白含量（Reticulocyte hemoglobin content,RET-He）是VLBWI贫血的独立保护因素;剖宫产、孕期贫血是VLBWI贫血的独立危险因素。构建的列线图模型拟合情况良好,预测VLBWI贫血的AUC值为0.921（0.907~0.935）。结论出生体重、出生胎龄、出生时Hb、出生时Hct、出生时RET-He、剖宫产、孕期贫血与VLBWI贫血密切相关,临床医师及孕产妇需关注孕期保健,控制高危因素,提高生产预后。

关键词: 极低出生体重儿, 贫血, 影响因素, 列线图模型

Abstract: Objective To explore the related factors of very low birth weight infant （VLBWI） anemia, and establish a nomogram prediction model. Methods We retrospectively selected VLBWI admitted to the neonatology department and NICU of our hospital from January 2016 to July 2021 as the research objects,and recorded their general data,prenatal data,postnatal data,and complications during hospitalization. The subjects were divided into anemia group（73 cases）and non-anemia group （81 cases）according to whether they are anemia. Logistic regression analysis was used to screen the related factors of anemia of VLBWI. The nomogram prediction model was established,and the ROC curve was used to evaluate the predictive ability of the nomogram model for VLBWI anemia. Results Multivariate logistic regression results showed birth weight,gestational age at birth,hemoglobin（Hb）at birth,hematocrit（Hct）at birth,and reticulocyte hemoglobin content（RET-He）at birth were independent protective factors for anemia of VLBWI, cesarean section and pregnancy anemia were independent risk factors for anemia of VLBWI. The constructed nomogram model fits well, and the AUC value of the nomogram model predicting anemia of VLBWI was 0.921 （0.907~0.935）. Conclusion Birth weight,gestational age at birth,Hb at birth,Hct at birth,RET-He at birth,cesarean section,and anemia during pregnancy are closely related to VLBWI anemia. Clinicians and pregnant women must pay attention to health care during pregnancy control high-risk factors, and improve prognosis of delivery.

Key words: Very low birth weight infants, Anemia, Influencing factors, Nomogram model

中图分类号:

R722.1

赵兴丹, 符小玲, 翁艾罕. 极低出生体重儿贫血相关因素及评估模型建立^*[J]. 临床输血与检验, 2022, 24(2): 202-206.

ZHAO Xing-dan, FU Xiao-ling, WENG Ai-han. Anemia-Related Factors in Very Low Birth Weight Infants and Establishment of an Assessment Model[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(2): 202-206.

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极低出生体重儿贫血相关因素及评估模型建立^*

Anemia-Related Factors in Very Low Birth Weight Infants and Establishment of an Assessment Model

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