[1] PONOMARENKO L A,SCHEDIN F,KATSNELSON M I,et al.Chaotic Dirac billiard in graphene quantum dots[J]. Science,2008,320(5874):356-358. [2] CHUNG S,REVIA R A,ZHANG M Q.Graphene quantum dots and their applications in bioimaging,biosensing,and therapy[J].Adv Mater,2021,33(22):e1904362. [3] GHAEIDAMINI M,BERNSON D,SASANIAN N,et al.Graphene oxide sheets and quantum dots inhibit α-synuclein amyloid formation by different mechanisms[J]. Nanoscale,2020,12(37):19450-19460. [4] ORECCHIONI M,MÉNARD-MOYON C,DELOGU L G,et al. Graphene and the immune system:challenges and potentiality[J]. Adv Drug Deliv Rev,2016,105(Pt B):163-175. [5] ARVAND M,HEMMATI S.Analytical methodology for the electro-catalytic determination of estradiol and progesterone based on graphene quantum dots and poly(sulfosalicylic acid) co-modified electrode[J]. Talanta,2017,174:243-255. [6] VOLAREVIC V,VOLAREVIC V,PAUNOVIC V,et al.Large graphene quantum dots alleviate immune-mediated liver damage[J].ACS Nano,2014,8(12):12098-12109. [7] NAAHIDI S,JAFARI M,EDALAT F,et al.Biocompatibility of engineered nanoparticles for drug delivery[J]. J Control Release,2013,166(2):182-194. [8] TANG L,JI R,CAO X,et al.Deep ultraviolet photoluminescence of water-soluble self-passivated graphene quantum dots[J].ACS Nano,2012,6(6):5102-5110. [9] YUAN X C,LIU Z M,GUO Z Y,et al.Cellular distribution and cytotoxicity of graphene quantum dots with different functional groups[J].Nanoscale Res Lett,2014,9(1):108. [10] XIE Y C,WAN B,YANG Y,et al.Cytotoxicity and autophagy induction by graphene quantum dots with different functional groups[J]. J Environ Sci (China),2019,77:198-209. [11] CHONG Y,MA Y F,SHEN H,et al.The in vitro and in vivo toxicity of graphene quantum dots[J]. Biomaterials,2014,35(19):5041-5048. [12] ALARIFI S,ALI D,VERMA A,et al.Single-walled carbon nanotubes induce cytotoxicity and DNA damage via reactive oxygen species in human hepatocarcinoma cells[J]. In Vitro Cell Dev Biol Anim,2014,50(8):714-722. [13] WANG A X,PU K F,DONG B,et al.Role of surface charge and oxidative stress in cytotoxicity and genotoxicity of graphene oxide towards human lung fibroblast cells[J]. J Appl Toxicol,2013,33(10):1156-1164. [14] WU C Y,WANG C,HAN T,et al.Insight into the cellular internalization and cytotoxicity of graphene quantum dots[J]. Adv Healthc Mater,2013,2(12):1613-1619. [15] KIM J,NAFIUJJAMAN M,NURUNNABI M,et al.Hemorheological characteristics of red blood cells exposed to surface functionalized graphene quantum dots[J]. Food Chem Toxicol,2016,97:346-353. [16] NURUNNABI M,KHATUN Z,HUH K M,et al.In vivo biodistribution and toxicology of carboxylated graphene quantum dots[J]. ACS Nano,2013,7(8):6858-6867. [17] SCHROEDER K L,GOREHAM R V,NANN T.Graphene quantum dots for theranostics and bioimaging[J]. Pharm Res,2016,33(10):2337-2357. [18] ZHAO Y L,LIU Q,SHAKOOR S,et al.Transgeneration al safety of nitrogen-doped graphene quantum dots and the underlying cellular mechanism in Caenorhabditis elegans[J]. Toxicol Res,2014,4(2):270-280. [19] Abdullah-Al-Nahain,LEE J E,IN I,et al.Target delivery and cell imaging using hyaluronic acid-functionalized graphene quantum dots[J].Mol Pharm,2013,10(10):3736-3744. [20] ZHANG D,ZHANG Z F,WU Y,et al.Systematic evaluation of graphene quantum dot toxicity to male mouse sexual behaviors,reproductive and offspring health[J]. Biomaterials,2019,194:215-232. [21] ZHANG X D,YANG J,SONG S S,et al.Passing through the renal clearance barrier:toward ultrasmall sizes with stable ligands for potential clinical applications[J]. Int J Nanomedicine,2014,9:2069-2072. [22] MARTÍN C,JUN G,SCHURHAMMER R,et al. Enzymatic degradation of graphene quantum dots by human peroxidases[J]. Small,2019,15(52):e1905405. [23] NATHAN C,CUNNINGHAM-BUSSEL A.Beyond oxidative stress:an immunologist's guide to reactive oxygen species[J]. Nat Rev Immunol,2013,13(5):349-361. [24] CHRISTENSEN I L,SUN Y P,JUZENAS P.Carbon dots as antioxidants and prooxidants[J]. J Biomed Nanotechnol,2011,7(5):667-676. [25] FERNANDO K A S,SAHU S,LIU Y M,et al. Carbon quantum dots and applications in photocatalytic energy conversion[J]. ACS Appl Mater Interfaces,2015,7(16):8363-8376. [26] CHONG Y,GE C C,FANG G,et al.Crossover between anti- and pro-oxidant activities of graphene quantum dots in the absence or presence of light[J]. ACS Nano,2016,10(9):8690-8699. [27] NILEWSKI L,MENDOZA K,JALILOV A S,et al.Highly oxidized graphene quantum dots from coal as efficient antioxidants[J]. ACS Appl Mater Interfaces,2019,11(18):16815-16821. [28] ROSTAMZADEH F,SHADKAM-FARROKHI M,JAFARINEJAD-FARSANGI S,et al.PEGylated graphene quantum dot improved cardiac function in rats with myocardial infarction:morphological,oxidative stress,and toxicological evidences[J].Oxid Med Cell Longev,2021,2021:8569225. [29] WANG L F,LI Y,ZHAO L,et al.Recent advances in ultrathin two-dimensional materials and biomedical applications for reactive oxygen species generation and scavenging[J]. Nanoscale,2020,12(38):19516-19535. [30] WANG Y M,KONG W H,WANG L F,et al.Optimizing oxygen functional groups in graphene quantum dots for improved antioxidant mechanism[J]. Phys Chem Chem Phys,2019,21(3):1336-1343. [31] WANG H,YU D Q,FANG J,et al.Phenol-like group functionalized graphene quantum dots structurally mimicking natural antioxidants for highly efficient acute kidney injury treatment[J].Chem Sci,2020,11(47):12721-12730. [32] Chen W,Ouyang J,Liu H,et al.Black phosphorus nanosheet-based drug delivery system for synergistic photodynamic/photothermal/chemotherapy of cancer[J]. Adv Mater,2017,29(5):2017 Feb;29(5). [33] ZHAO S J,LAN M H,ZHU X Y,et al.Green synthesis of bifunctional fluorescent carbon dots from garlic for cellular imaging and free radical scavenging[J]. ACS Appl Mater Interfaces,2015,7(31):17054-17060. [34] WANG L F,LI Y,WANG Y M,et al.Chlorine-doped graphene quantum dots with enhanced anti- and pro-oxidant properties[J]. ACS Appl Mater Interfaces,2019,11(24):21822-21829. [35] RUIZ V,YATE L,GARCÍA I,et al.Tuning the antioxidant activity of graphene quantum dots:protective nanomaterials against dye decoloration[J]. Carbon,2017,116:366-374. [36] LI Y,LI S,WANG Y M,et al.Electrochemical synthesis of phosphorus-doped graphene quantum dots for free radical scavenging[J].Phys Chem Chem Phys,2017,19(18):11631-11638. [37] OH B,LEE C H.Development of thiolated-graphene quantum dots for regulation of ROS in macrophages[J]. Pharm Res,2016,33(11):2736-2747. [38] SCHIEBER M,CHANDEL N S.ROS function in redox signaling and oxidative stress[J]. Curr Biol,2014,24(10):R453-R462. [39] JACQUEL A,OBBA S,BOYER L,et al.Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions[J]. Blood,2012,119(19):4527-4531. [40] NIMMERJAHN F,MILOSEVIC S,BEHRENDS U,et al.Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy[J]. Eur J Immunol,2003,33(5):1250-1259. [41] PUA H H,DZHAGALOV I,CHUCK M,et al.A critical role for the autophagy gene Atg5 in T cell survival and proliferation[J]. J Exp Med,2007,204(1):25-31. [42] MARKOVIC Z M,RISTIC B Z,ARSIKIN K M,et al.Graphene quantum dots as autophagy-inducing photodynamic agents[J]. Biomaterials,2012,33(29): 7084-7092. [43] QIN Y R,ZHOU Z W,PAN S T,et al.Graphene quantum dots induce apoptosis,autophagy,and inflammatory response via p38 mitogen-activated protein kinase and nuclear factor-κB mediated signaling pathways in activated THP-1 macrophages[J]. Toxicology,2015,327:62-76. [44] KRUNIĆ M,RISTIĆ B,BOŠNJAK M,et al. Graphene quantum dot antioxidant and proautophagic actions protect SH-SY5Y neuroblastoma cells from oxidative stress-mediated apoptotic death[J]. Free Radic Biol Med,2021,177:167-180. [45] TOSIC J,STANOJEVIC Z,VIDICEVIC S,et al.Graphene quantum dots inhibit T cell-mediated neuroinflammation in rats[J]. Neuropharmacology,2019,146:95-108. [46] QIN Z H.Autophagy:Biology and Diseases[M]. Singapore:Springer Singapore,2019. [47] LEE B C,LEE J Y,KIM J,et al. Graphene quantum dots as anti-inflammatory therapy for colitis[J]. Sci Adv,2020,6(18):eaaz2630. [48] MILDNER A,JUNG S.Development and function of dendritic cell subsets[J]. Immunity,2014,40(5):642-656. [49] RAKER V K,DOMOGALLA M P,STEINBRINK K.Tolerogenic dendritic cells for regulatory T cell induction in man[J]. Front Immunol,2015,6:569. [50] CADWELL K.Crosstalk between autophagy and inflammatory signalling pathways:balancing defence and homeostasis[J]. Nat Rev Immunol,2016,16(11):661-675. [51] PERAL DE CASTRO C,JONES S A,NÍ CHEALLAIGH C,et al. Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion[J]. J Immunol,2012,189(8):4144-4153. [52] SAID A,BOCK S,LAJQI T,et al.Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells[J]. J Immunol,2014,193(12):6135-6143. [53] REED M,MORRIS S H,OWCZARCZYK A B,et al.Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1[J]. Mucosal Immunol,2015,8(5):1118-1130. [54] KIM J,KUNDU M,VIOLLET B,et al.AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1[J]. Nat Cell Biol,2011,13(2):132-141. [55] TOMIĆ S,JANJETOVIĆ K,MIHAJLOVIĆ D,et al.Graphene quantum dots suppress proinflammatory T cell responses via autophagy-dependent induction of tolerogenic dendritic cells[J]. Biomaterials,2017,146:13-28. [56] DOBROVOLSKAIA M A,MCNEIL S E.Immunological properties of engineered nanomaterials[J]. Nat Nanotechnol,2007,2(8):469-478. [57] KHODADADEI F,SAFARIAN S,GHANBARI N.Methotrexate-loaded nitrogen-doped graphene quantum dots nanocarriers as an efficient anticancer drug delivery system[J]. Mater Sci Eng C Mater Biol Appl,2017,79:280-285. |