低氧环境下VEGF及其受体的造血调控作用及机制研究进展*

doi:10.3969/j.issn.1671-2587.2022.05.023

临床输血与检验 ›› 2022, Vol. 24 ›› Issue (5): 676-680.DOI: 10.3969/j.issn.1671-2587.2022.05.023

• 综述 • 上一篇

低氧环境下VEGF及其受体的造血调控作用及机制研究进展^*

李治材, 肖军, 李翠莹

100142 北京,空军特色医学中心（李治材,肖军,李翠莹）; 安徽医科大学第五临床学院空军特色医学中心（李治材）

收稿日期:2022-07-20 出版日期:2022-10-20 发布日期:2022-10-31
通讯作者: 李翠莹,女,主任技师,硕士研究生导师,主要从事临床输血及高原输血研究,（E-mail）licuiying2013@qq.com。
作者简介:李治材（1994-）,男,四川成都人,硕士研究生在读,主要从事临床检验诊断学方面研究,（E-mail）：271154258@qq.com。
基金资助:
^*本课题受国家自然科学基金（NO.81971778）资助

Received:2022-07-20 Online:2022-10-20 Published:2022-10-31

摘要/Abstract

摘要： 血管内皮生长因子（vascular endothelial growth factor,VEGF）属于血小板衍生的生长因子超家族,低氧是调节其生成的重要因素之一,通过调节其表达,进而影响造血过程。VEGF与造血的关系逐渐得到证实,主要通过内分泌或旁分泌途径而发挥调节作用。关于VEGF及其受体的认识多与血管形成有关,但VEGF及其受体在胚胎和成人造血以及造血重建等方面发挥着更加重要的作用。VEGFR-1、VEGFR-2在造血细胞发育过程不同阶段的表达对造血细胞的增殖、分化、迁移有着重要的影响。此外,VEGF及其受体与恶性血液病和异常造血的发生关系密切,阻断VEGF/VEGFR通路已经成为了治疗这些疾病的重要靶点。本文拟对VEGF及其受体在造血发生、造血细胞发育以及异常造血过程中的作用和机制进行梳理和综述。

关键词: 低氧, VEGF, VEGFR-1, VEGFR-2, 造血

中图分类号:

R363

李治材, 肖军, 李翠莹. 低氧环境下VEGF及其受体的造血调控作用及机制研究进展^*[J]. 临床输血与检验, 2022, 24(5): 676-680.

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低氧环境下VEGF及其受体的造血调控作用及机制研究进展^*

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