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临床输血与检验

临床输血与检验 ›› 2016, Vol. 18 ›› Issue (2): 137-139.DOI: 10.3969/j.issn.1671-2587.2016.02.015

• 临床检验研究 • 上一篇    下一篇

Id-1、VEGF和MMP-9在宫颈鳞状细胞癌中的表达及意义

陈静,李聪   

  1. 400014 重庆市急救医疗中心病理科（陈静）; 重庆医科大学附属第一医院妇产科（李聪）
  • 收稿日期:2016-01-12 修回日期:2016-09-21 出版日期:2016-04-20 发布日期:2016-09-21
  • 作者简介:陈静（1980-）,女,重庆人,主治医师,学士,主要从事临床病理诊断工作,（E-mail）17097101@qq.com。

The Expression and Significance of Id-1, VEGF MMP-9 in the Cervical Squamous Cell Carcinoma

CHEN Jing, LI Cong   

  1. Chongqing Emergency Medical Center 400014
  • Received:2016-01-12 Revised:2016-09-21 Online:2016-04-20 Published:2016-09-21

PDF

566

被引次数

6

摘要： 目的探讨细胞分化抑制因子-1（Id-1）、血管内皮生长因子（VEGF）和基质金属蛋白酶-9（MMP-9）在正常宫颈组织、宫颈原位癌及宫颈鳞状细胞癌组织中的表达及临床病理学意义。方法采用免疫组织化学方法对20例宫颈正常组织、16例宫颈原位癌及74例宫颈鳞状细胞癌标本进行 ID-1、VEGF和MMP-9检测。结果宫颈鳞状细胞癌组织中id-1、VEGF和MMP-9的阳性表达明显高于正常组织和宫颈原位癌（P<0.05）。id-1、VEGF和MMP-9的阳性表达与临床分期及肿瘤的组织学分级有关（P<0.05）,与患者年龄无关（P>0.05）;id-1与VEGF和MMP-9蛋白表达呈正相关（rs=0.425,P <0.05; rs =0.313,P <0.05）。结论ID-1、VEGF和MMP-9的表达异常与宫颈癌的发生、发展有关,三者联合检测可作为宫颈癌的诊断和预后判断的重要指标。

关键词: 宫颈癌, 细胞分化抑制因子-1, 血管内皮生长因子, 基质金属蛋白酶-9

Abstract: ObjectiveTo investigate the expression and significance of inhibition of cell differentiation factor -1 (inhibitor of differentiation or inhibitor of DNA binding, id-1), vascular endothelial growth factor (vascular endothelial growth factor, VEGF) and matrix metalloproteinase-9 (matrix metalloproteinase-9, MMP-9) in normal cervical tissue, cervical carcinoma in situ and cervical squamous cell carcinoma. MethodsThe expression levels of Id-1, VEGF and MMP-9 proteins in normal tissues (n=20), cervical carcinoma in situ (n =16) and cervical squamous cell carcinoma(n =74)were examined by immunohistochemistry. ResultThe positive expression rates of Id-1, VEGF and MMP-9 in cervical squamous cell carcinora was gradually increased (P<0.05) than normal tissues, cervical carcinoma in situ, cervical carcinoma.The positive expression of Id-1, VEGF and MMP-9 was related to that of FIGO stage, histological stage(P<0.05), but it was not related to the age (P >0.05). Id-1 protein was positively related to that of VEGF (rs=0.809, P <0.05) and MMP-9 (rs=0.837, P <0.05). ConclusionThis study reveals that Id-1, VEGF and MMP-9 takes part in development and progression of cervical carcinoma. Both VEGF and MMP-9 ,and Id-1 are important biomarkers in the of diagnosis and prognosis of cervical carcinoma.

Key words: Cervical, carcinoma, Id-1, VEGF, MMP-9

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