1型糖尿病住院患者血尿酸与糖尿病肾脏疾病的关系*

doi:10.3969/j.issn.1671-2587.2019.03.014

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (3): 273-276.DOI: 10.3969/j.issn.1671-2587.2019.03.014

1型糖尿病住院患者血尿酸与糖尿病肾脏疾病的关系*

赵俐丽, 叶山东

230001 合肥，中国科学技术大学附属第一医院安徽省立医院内分泌科

收稿日期:2018-04-03 出版日期:2019-06-20 发布日期:2019-06-17
通讯作者: 叶山东（1964-）,男,安徽泾县人,主任医师,博士生导师,主要从事糖尿病肾病研究工作,（E-mail）ysd196406@163.com。
作者简介:赵俐丽（1983-）,女,安徽合肥人,主治医师,硕士,主要从事糖尿病肾病研究工作,(Tel)13637062396（E-mail）Zhaolili198303@foxmail.com。
基金资助:
*本课题受安徽省中央引导地方科技发展专项（No.201707d08050016）资助

The Relationship Between Serum Uric Acid Level and Nephropathy in Inpatients With Type 1 Diabetic Mellitus

ZHAO Li-li, YE Shandong

Department of Endocrinology,The First Affiliated Hospital of USTC, Hefei, Anhui, 230001

Received:2018-04-03 Online:2019-06-20 Published:2019-06-17

摘要/Abstract

摘要： 目的评估血尿酸预测1型糖尿病患者糖尿病肾脏疾病发生的价值。方法采用横断面回顾性研究方法,调阅186例1型糖尿病患者资料,分为：正常蛋白尿组（n=117）、微量蛋白尿组（n=47）、大量蛋白尿组（n=22）。结果 ①大量蛋白尿组较正常蛋白尿组血尿酸明显升高,差异有统计学意义（P<; 0.05）,其余组间比较差异无统计学意义;②血尿酸与体重指数、收缩压、血肌酐、尿素氮、甘油三酯呈正相关(P<; 0.05）。③logistic回归分析结果显示糖化血红蛋白A1C（(R值 1.372,95%CI 1.111~1.695）和血尿酸（R值 1.006,95%CI 1.000~1.011）是影响糖尿病肾脏疾病发生的独立危险因素。结论血尿酸升高是1型糖尿病患者发生糖尿病肾脏疾病的独立危险因素。

关键词: 糖尿病1型, 尿酸, 糖尿病肾病疾病, 危险因素

Abstract: Objective To analyze the relationship between serum uric acid level and urinary albumin/urinary creatinine(UACR), and to evaluate the serum uric acid level in predicting the occurrence of diabetic kidney disease (DKD) in patients with type 1 diabetic mellitus. Methods Based on retrospectively cross-sectional study method,186 cases of type 1 diabetic mellitus were enrolled who were treated in the hospital from August 2015 to December 2017. The patients were divided into three groups according to UACR: non-diabetic nephropathy group (n=117), micro-albuminuria group（n=47）,and macro-albuminuria group (n=22). Results The serum uric acid level in macro-albuminuria group was higher than that in non-diabetic nephropathy group (P<0.05). The serum uric acid level had the positive correlation with the gender, body mass index, systolic pressure, serum creatinine, blood urea nitrogen and triglyceride. Logistic regression analysis showed that HbA1c and serum uric acid were independent risk factors of DKD. Conclusions The serum uric acid is the independent risk factor of diabetes kidney disease in patients with type 1 diabetic mellitus.

Key words: Type 1 diabetes mellitus, Uric acid, Diabetic nephropathy, Risk factors

中图分类号:

R587.1R446.11

赵俐丽, 叶山东. 1型糖尿病住院患者血尿酸与糖尿病肾脏疾病的关系*[J]. 临床输血与检验, 2019, 21(3): 273-276.

ZHAO Li-li, YE Shandong. The Relationship Between Serum Uric Acid Level and Nephropathy in Inpatients With Type 1 Diabetic Mellitus[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2019, 21(3): 273-276.

参考文献

1 Bjornstad P,Maahs D,Rivard C,et al.Serum uric acid predicts vascular complications in adults with type 1 diabetes: the coronary artery calcification in type 1 diabetes study[J].Acta Diabetol,2014,51(5):783-791.
2 Ren Y,Ji L,Mu Y,et al.Uric acid,renal function and risk of hypoglycaemia in Chinese type 2 diabetes patients[J].Diabetes Metab Res Rev,2016,32(8):875-882.
3 Alberti K,Zimmet P.Definition,diagnosis and classification of diabetes mellitus and its complications.Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation[J].Diabet Med,1998,15(7):539-553.
4 Tuttle K,Bakris G,Bilous R,et al.Diabetic kidney disease: a report from an ADA Consensus Conference[J]. Diabetes Care,2014,37(10):2864-2883.
5 Jalal D,Rivard C,Johnson R,et al.Serum uric acid levels predict the development of albuminuria over 6 years in patients with type 1 diabetes: findings from the Coronary Artery Calcification in Type 1 Diabetes study[J]. Nephron Dial Transplant,2010,25(6):1865-1869.
6 Klisic A,Kocic G,Kavaric N,et al.Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2[J].Clin Exp Med,2018,18(2):283-290.
7 Liang C,Lin P,Lee M,et al.Association of Serum Uric Acid Concentration with Diabetic Retinopathy and Albuminuria in Taiwanese Patients with Type 2 Diabetes Mellitus[J].Int J Mol Sci,2016,17(8):1248.
8 Yan D,Wang J,Jiang F,et al.A causal relationship between uric acid and diabetic macrovascular disease in Chinese type 2 diabetes patients: A Mendelian randomization analysis[J].Int J Cardiol,2016,214:194-199.
9 Chang Y,Lei C,Lin K,et al.Serum uric acid level as an indicator for CKD regression and progression in patients with type 2 diabetes mellitus-a 4.6-year cohort study[J].Diabetes Metab Res Rev,2016,32(6):557-564.
10 De C,Viazzi F,Pacilli A,et al.Serum Uric Acid and Risk of CKD in Type 2 Diabetes[J].Clin J Am Soc Nephrol,2015,10(11):1921-1929.
11 Hayashino Y,Okamura S,Tsujii S,et al.Association of serum uric acid levels with the risk of development or progression of albuminuria among Japanese patients with type 2 diabetes: a prospective cohort study [Diabetes Distress and Care Registry at Tenri (DDCRT 10)][J]. Acta Diabetol,2016,53(4):599-607.
12 Lytvyn Y,Mahmud F,Daneman D,et al.Association Between Plasma Uric Acid Levels and Cardiorenal Function in Adolescents With Type 1 Diabetes[J].Diabetes Care,2016,39(4):611-616.
13 Matheus A,Tibiriçá E,da Silva,P,et al.Uric acid levels are associated with microvascular endothelial dysfunction in patients with Type 1 diabetes[J]. Diabet Med,2011,28(10):1188-1193.
14 Lytvyn Y,Škrti M,Yang G K,et al. Plasma uric acid effects on glomerular haemodynamic profile of patients with uncomplicated Type 1 diabetes mellitus[J]. Diabet Med,2016,33(8):1102-1111.
15 Lytvyn Y,Har R,Locke A,et al. Renal and Vascular Effects of Uric Acid Lowering in Normouricemic Patients With Uncomplicated Type 1 Diabetes[J]. Diabetes,2017,66(7):1939-1949.
16 Yan D,Wang J,Jiang F,et al.Association between serum uric acid related genetic loci and diabetic kidney disease in the Chinese type 2 diabetes patients[J].J Diabetes Complications,2016,30(5):798-802.
17 Krolewski A S,Niewczas M A,Skupien J,et al.Early progressive renal decline precedes the onset of microalbuminuria and its progression to macroalbuminuria[J]. Diabetes Care,2014,37(1):226-234.
18 Pan S,He C H,Ma Y T,et al.Serum uric acid levels are associated with high blood pressure in Chinese children and adolescents aged 10-15 years[J].J Hypertens,2014,32(5):998-1003.
19 Baliarsingh S,Sharma N.Serum uric acid level is an indicator of total cholesterol and low density lipoprotein cholesterol in men below 45 years in age but not older males[J]. Clin Lab,2012,58(5-6):545-550.
20 Kuwata H,Okamura S,Hayashino Y,et al.Serum uric acid levels are associated with increased risk of newly developed diabetic retinopathy among Japanese male patients with type 2 diabetes: A prospective cohort study (diabetes distress and care registry at Tenri [DDCRT 13])[J]. Diabetes Metab Res Rev,2017,33(7).

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1型糖尿病住院患者血尿酸与糖尿病肾脏疾病的关系*

The Relationship Between Serum Uric Acid Level and Nephropathy in Inpatients With Type 1 Diabetic Mellitus

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