血浆制品中凝血因子Ⅷ含量及抽检结果的影响因素分析*

doi:10.3969/j.issn.1671-2587.2024.05.009

临床输血与检验 ›› 2024, Vol. 26 ›› Issue (5): 630-637.DOI: 10.3969/j.issn.1671-2587.2024.05.009

血浆制品中凝血因子Ⅷ含量及抽检结果的影响因素分析^*

郝梦玲, 汤龙海, 金一鸣, 肖琦, 方敏

苏州市中心血站,江苏苏州 215006

收稿日期:2024-07-01 出版日期:2024-10-20 发布日期:2024-09-20
通讯作者: 方敏,主要从事血液制品质量管理,（E-mail）gina0912@sina.com。
作者简介:郝梦玲,主要从事血液制品质量控制,（E-mail）782275596@qq.com。
基金资助:
*本课题受苏州市公卫专项（No.GWZX202303）; 苏州市卫生科技项目（No.SKY2023077）的资助

Analysis of Coagulation Factor Ⅷ Levels and Quality Inspection Results in Plasma Products

HAO Mengling, TANG Longhai, JIN Yiming, XIAO Qi, FANG Min

Suzhou Blood Center, Suzhou, Jiangsu 215006

Received:2024-07-01 Online:2024-10-20 Published:2024-09-20

摘要/Abstract

摘要： 目的探讨献血者的血型、性别、年龄及其交互作用如何影响冷沉淀和新鲜冰冻血浆中凝血因子Ⅷ（FⅧ）的含量及其质量抽检结果,以期为血液制品质量控制和临床输血策略的优化提供科学依据。方法回顾性分析2022年—2023年间本站对456袋冷沉淀和128袋新鲜冰冻血浆的质量监测数据,并利用卡方检验、独立样本t检验、ANOVA、LSD检验以及多元线性和二元logistic回归等方法对各组数据进行分析。结果冷沉淀与新鲜冰冻血浆中FⅧ的不合格率显著高于其他质控项目。冷沉淀中AB型的FⅧ含量最高,O型最低;新鲜冰冻血浆中O型FⅧ含量同样最低。冷沉淀中青年组的FⅧ含量最低,中老年组最高;新鲜冰冻血浆中青年组的FⅧ含量显著低于中年组与中老年组。血型与年龄均独立影响冷沉淀及新鲜冰冻血浆中FⅧ含量,血型、性别与年龄的交互作用均未对其产生显著影响。冷沉淀中AB型及年龄的增长是FⅧ含量的正向影响因素,而O型为负向影响因素;新鲜血浆中O型同样表现为负向影响,中年及老年组为正影响因素。此外,O型血与冷沉淀和新鲜冰冻血浆的不合格风险显著相关。结论 FⅧ含量的不合格率在冷沉淀及新鲜冰冻血浆质量控制项目中最高,血型和年龄是影响FⅧ含量的关键因素,其中O型血显著增加了冷沉淀及新鲜冰冻血浆FⅧ不合格的风险。

关键词: 冷沉淀, 新鲜冰冻血浆, 凝血因子Ⅷ, 质量控制, 献血者特征

Abstract: Objective To investigate how donor blood type, gender, age, and their interactions influence the levels of Factor Ⅷ (FⅧ) in cryoprecipitate and fresh frozen plasma (FFP), as well as the rate of product qualified. This study aims to provide scientific evidence for improving blood product quality monitoring and optimizing clinical transfusion strategies. Methods A retrospective analysis was conducted on quality monitoring data for 456 bags of cryoprecipitate and 128 bags of FFP collected at our institute from 2022 to 2023. Data were analyzed using chi-square tests, independent sample t-tests, ANOVA, LSD tests, and multiple linear and binary logistic regression analyses. Results The unqualified rate of FⅧ in cryoprecipitate and FFP was significantly higher than in other quality control items. In cryoprecipitate, the FⅧ level was the highest in AB blood type and the lowest in O blood type. Similarly, in FFP, O blood type had the lowest FⅧ levels. The FⅧ level in cryoprecipitate was the lowest in the younger age group and the highest in the elderly groups. In FFP, the FⅧ level in the younger age group was significantly lower than in the middle-aged and elderly groups. Both blood type and age independently affected FⅧ levels in cryoprecipitate and FFP, while the interactions between blood type, gender, and age showed no significant impact. AB blood type and increasing age positively influenced FⅧ levels in cryoprecipitate, whereas O blood type had a negative impact. Similarly, in FFP, O blood type negatively affected FⅧ levels, while the middle-aged and elderly groups had a positive impact. Additionally, O blood type was significantly associated with a higher risk of non-conformance in both cryoprecipitate and FFP. Conclusion The unqualified rate for FⅧ levels is the highest among quality control items for cryoprecipitate and FFP. Blood type and age are key factors influencing FⅧ levels, with O blood type significantly increasing the risk of unqualified FⅧ in both cryoprecipitate and FFP.

Key words: Cryoprecipitate, Fresh frozen plasma, Coagulation factor Ⅷ, Quality control, Blood donor characteristics

中图分类号:

R457.1⁺4

郝梦玲, 汤龙海, 金一鸣, 肖琦, 方敏. 血浆制品中凝血因子Ⅷ含量及抽检结果的影响因素分析^*[J]. 临床输血与检验, 2024, 26(5): 630-637.

HAO Mengling, TANG Longhai, JIN Yiming, XIAO Qi, FANG Min. Analysis of Coagulation Factor Ⅷ Levels and Quality Inspection Results in Plasma Products[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2024, 26(5): 630-637.

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血浆制品中凝血因子Ⅷ含量及抽检结果的影响因素分析^*

Analysis of Coagulation Factor Ⅷ Levels and Quality Inspection Results in Plasma Products

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