输血医学3.0：输血医学的智能化与个性化*

doi:10.3969/j.issn.1671-2587.2025.06.002

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (6): 754-760.DOI: 10.3969/j.issn.1671-2587.2025.06.002

输血医学3.0：输血医学的智能化与个性化^*

葛霜, 尚玮, 于洋, 汪德清

解放军总医院第一医学中心输血医学科,北京 100039

收稿日期:2025-06-19 出版日期:2025-12-20 发布日期:2025-12-24
通讯作者: 汪德清,主要从事临床输血风险控制研究,E-mail：deqingw@vip.sina.com。共同通信作者：于洋,主要从事单采治疗、输血免疫和野战输血研究,E-mail：yuyangpla301@163.com。
作者简介:葛霜,主要从事临床检验诊断学研究,E-mail：geshuang3322@163.com。
基金资助:
^*本课题受军队“十三五”全军后勤科研重点项目（No.BWS16J006）资助

Transfusion Medicine 3.0: Intelligence and Personalization in Transfusion Medicine

GE Shuang, SHANG Wei, YU Yang, WANG Deqing

Department of Transfusion Medicine, The First Medical Center of Chinese PLA General Hospital, Beijing 100039

Received:2025-06-19 Online:2025-12-20 Published:2025-12-24

摘要/Abstract

摘要： 输血医学正经历着从传统经验医学向现代精准医疗的重要转变。我们从硬件（血液成分）和软件（技术与管理体系）两个维度,系统梳理了输血医学的发展历程：从血型鉴定与全血输注为特征的1.0认知启蒙阶段,经由成分血制备、限制性输注策略与全过程质量控制为特征的2.0发展阶段,到如今以智能化与个性化为标志的3.0创新阶段。3.0时代,基因编辑技术促进了通用血液的开发,干细胞定向分化实现了血细胞体外培养,人工智能的引入优化了输血决策与血液管理。这些技术创新正推动输血医学进入精准医疗新纪元。我们深入分析了新兴技术在输血医学中的应用前景,探讨了多学科交叉融合带来的机遇与挑战,为输血医学的未来发展提供了新的思路。

关键词: 输血医学, 精准医疗, 智能化, 个性化

Abstract: Transfusion medicine is undergoing a significant transformation from traditional empirical medicine to modern precision medicine. This article systematically reviews the development of transfusion medicine from two dimensions: hardware (blood component research) and software (management system). The evolution encompasses three stages: the 1.0 cognitive initiation phase characterized by blood typing and whole blood transfusion, the 2.0 development phase marked by blood component preparation and standardized management, and the current 3.0 innovation phase featuring intelligence and personalization. In the 3.0 era, gene editing technology has facilitated the development of universal blood, the directed differentiation of stem cells has enabled the in vitro culture of blood cells, and the introduction of artificial intelligence has optimized transfusion decision-making and blood management. These technological innovations are driving transfusion medicine into a new era of precision medicine. This article provides an in-depth analysis of emerging technologies' applications in transfusion medicine and explores the opportunities and challenges brought by multidisciplinary integration, offering new perspectives for the future development of transfusion medicine.

Key words: Transfusion Medicine, Precision medicine, Intelligence, Personalization

中图分类号:

R457

葛霜, 尚玮, 于洋, 汪德清. 输血医学3.0：输血医学的智能化与个性化^*[J]. 临床输血与检验, 2025, 27(6): 754-760.

GE Shuang, SHANG Wei, YU Yang, WANG Deqing. Transfusion Medicine 3.0: Intelligence and Personalization in Transfusion Medicine[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(6): 754-760.

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输血医学3.0：输血医学的智能化与个性化^*

Transfusion Medicine 3.0: Intelligence and Personalization in Transfusion Medicine

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