2021—2022年度输血医学研究进展*

doi:10.3969/j.issn.1671-2587.2023.02.023

临床输血与检验 ›› 2023, Vol. 25 ›› Issue (2): 276-281.DOI: 10.3969/j.issn.1671-2587.2023.02.023

2021—2022年度输血医学研究进展^*

葛霜, 汪德清

100853 北京,解放军总医院第一医学中心输血医学科

收稿日期:2023-02-20 发布日期:2023-04-25
通讯作者: 汪德清,主任医师,教授,博士生导师,主要从事临床输血风险控制研究,（E-mail）deqingw@vip.sina.com。
作者简介:葛霜,主要从事临床输血风险控制研究,（E-mail）geshuang3322@163.com。
基金资助:
*本课题受战时血液安全保障关键技术研究战场应急救治全血安全处置技术及装置研究项目（No.BWS16J006）资助

Research Advances in Transfusion Medicine 2021-2022

GE Shuang, WANG De-qing

Department of Transfusion Medicine, The First Medical Center of Chinese PLA General Hospital, Beijing 100010

Received:2023-02-20 Published:2023-04-25

摘要/Abstract

摘要： 随着科研技术的不断革新进步以及科研工作的深入开展,输血医学的内容也在不断得到更新和补充。本文就2021—2022年度输血医学研究进展进行简要概述, 主要包含血液不同成分的作用和应用,输血医学学科交叉研究和前沿技术的应用,以及临床输血和治疗相关研究这三个方面,以期为我国输血医学学科建设和发展方向提供参考。

关键词: 输血医学, 研究进展

Abstract: With the continuous innovation and scientific and technological advances and the deepening of scientific research, the content of transfusion medicine is being constantly updated. This article provides a brief overview of the research progress in transfusion medicine from 2021 to 2022, including blood products uses, cross-disciplinary research and application of cutting-edge technologies, and research related to clinical transfusion and treatment, to provide a reference for discipline construction and development of transfusion medicine in China.

Key words: Transfusion medicine, Research advances

中图分类号:

R457.1

葛霜, 汪德清. 2021—2022年度输血医学研究进展^*[J]. 临床输血与检验, 2023, 25(2): 276-281.

GE Shuang, WANG De-qing. Research Advances in Transfusion Medicine 2021-2022[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(2): 276-281.

参考文献

[1] 贺敏威,孙苏静,周欠欠,等.2020年度输血医学科研新进展[J].临床输血与检验,2021,23(1):13-16.
[2] LAM L K M,MURPHY S,KOKKINAKI D,et al.DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia[J].Sci Transl Med,2021,13(616):eabj1008.
[3] XU C L,HE J,WANG H T,et al.Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis[J].Nat Immunol,2022,23(7):1109-1120.
[4] LIU D,DUAN L H,RODDA L B,et al.CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells[J].Science,2022,375(6581):eabi5965.
[5] ZHANG J R,ZHANG D,ZHAO J.CFNAs of RBCs affect the release of inflammatory factors through the expression of CaMKIV in macrophages[J].Transfus Apher Sci,2022,61(6):103494.
[6] ZHU C H,NIU Q J,YUAN X Y,et al.NonFreezable preservation of human red blood cells at-8 ℃[J].ACS Biomater Sci Eng,2022,8(6):2644-2653.
[7] DE BRUIN S,PETERS A L,WIJNBERGE M,et al.Storage of red blood cells in alkaline PAGGGM improves metabolism but has no effect on recovery after transfusion[J].Blood Adv,2022,6(13):3899-3910.
[8] RABCUKA J,BLONSKI S,MELI A,et al.Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells[J].Blood Adv,2022,6(18):5415-5428.
[9] HAY A,NEMKOV T,GAMBONI F,et al.S1P has a negative effect on RBC storage quality[J].Blood Adv,2022
[10] COSEMANS J M E M.Platelet-derived MMP-2 in the prevention of plaque formation:how many strokes is par?[J].Eur Heart J,2022,43(6):515-517.
[11] LEBERZAMMER J,AGTEN S M,BLANCHET X,et al.Targeting platelet-derived CXCL12 impedes arterial thrombosis[J].Blood,2022,139(17):2691-2705.
[12] SHAO B J,HOOVER C,SHI H P,et al.Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP[J].Blood,2022,139(16):2523-2533.
[13] REVOLLO L,MERRILL-SKOLOFF G,DE CEUNYNCK K,et al.The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation[J].Blood,2022,139(1):104-117.
[14] BORDON Y.Platelet-derived 5-HIAA helps neutrophils enter tissue[J].Nat Rev Immunol,2022,22(4):206-207.
[15] RAYES J.It takes guts to boost platelet reactivity and inflammation[J].Blood,2022,139(12):1781-1783.
[16] MCVEY M J,WEIDENFELD S,MAISHAN M,et al.Platelet extracellular vesicles mediate transfusion-related acute lung injury by imbalancing the sphingolipid rheostat[J].Blood,2021,137(5):690-701.
[17] COUVIDOU A,ANGÉNIEUX C,RUCH L,et al.Marginal zone B cells are responsible for the production of alloantibodies following platelet transfusion in mice[J].Blood Adv,2022
[18] KASIRER-FRIEDE A,PEUHU E,IVASKA J,et al.Platelet SHARPIN regulates platelet adhesion and inflammatory responses through associations with αIIbβ3 and LUBAC[J].Blood Adv,2022,6(8):2595-2607.
[19] LIU C C,WU D,XIA M J,et al.Characterization of cellular heterogeneity and an immune subpopulation of human megakaryocytes[J].Adv Sci (Weinh),2021,8(15):e2100921.
[20] SUN S,JIN C,SI J,et al.Single-cell analysis of ploidy and the transcriptome reveals functional and spatial divergency in murine megakaryopoiesis[J].Blood,2021,138(14):1211-1224.
[21] LI H J,WANG Z J,CHEN Z W,et al.Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis[J].Nat Commun,2021,12(1):2773.
[22] DEUTSCH E W,OMENN G S,SUN Z,et al.Advances and utility of the human plasma proteome[J].J Proteome Res,2021,20(12):5241-5263.
[23] STEVENSON-HOARE J,HESLEGRAVE A,LEONENKO G,et al.Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer’s disease[J].Brain,2023,146(2):690-699.
[24] DE MIGUEL Z,KHOURY N,BETLEY M J,et al.Exercise plasma boosts memory and dampens brain inflammation via clusterin[J].Nature,2021,600(7889):494-499.
[25] FANG F,XU L,LIANG L Q,et al.The accumulation of miR-125b-5p is indispensable for efficient erythroblast enucleation[J].Cell Death Dis,2022,13(10):886.
[26] WANG M,XU R,HUANG J T,et al.Molecular characteristics of the full-length genome of occult hepatitis B virus from blood donors in China[J].Sci Rep,2022,12(1):8194.
[27] ZHANG Y Y,HUANG G Q,YUAN Z H,et al.Profiling and bioinformatics analysis revealing differential circular RNA expression about storage lesion regulatory in stored red blood cells[J].Transfus Med Hemother,2021,49(2):76-87.
[28] QIN J H,ZHANG J,JIANG J N,et al.Direct chemical reprogramming of human cord blood erythroblasts to induced megakaryocytes that produce platelets[J].Cell Stem Cell,2022,29(8):1229-1245.e7.
[29] JIAN F,PENG Y,BIAN M H.Expression and bioinformatics analysis of key miRNAs in stored red blood cells[J].Transfus Med Hemother,2022,49(5):298-305.
[30] SUN Y X,CHENG Z Y,GUO Z P,et al.Preliminary study of genome-wide association identified novel susceptibility genes for hemorheological indexes in a Chinese population[J].Transfus Med Hemother,2022,49(6):346-357.
[31] MA S,WANG S,YE Y X,et al.Heterochronic parabiosis i
nduces stem cell revitalization and systemic rejuvenation across aged tissues[J].Cell Stem Cell,2022,29(6):990-1005.e10.
[32] SIVALINGAM J,YU S E,LIM Z R,et al.A scalable suspension platform for generating high-density cultures of universal red blood cells from human induced pluripotent stem cells[J].Stem Cell Rep,2021,16(1):182-197.
[33] EHREND E,MANNS P,HARENKAMP S,et al.Preanalyt ic depletion of medicinal anti-CD38 antibody from patient plasma for immunohematology testing[J].Blood,2021,138(9):814-817.
[34] FERRARI A,CASSANITI I,SAMMARTINO J C,et al.SARS-CoV-2 variants inactivation of plasma units using a riboflavin and ultraviolet light-based photochemical treatment[J].Transfus Apher Sci,2022,61(4):103398.
[35] AZHAR E I,HINDAWI S I,EL-KAFRAWY S A,et al.Amotosalen and ultraviolet A light treatment efficiently inactivates severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human plasma[J].Vox Sang,2021,116(6):673-681.
[36] LAROCHE A,SOULET D,BAZIN M,et al.Live imaging of platelets and neutrophils during antibody-mediated neurovascular thrombosis[J].Blood Adv,2022,6(12):3697-3702.
[37] SHAO J S,FENG L Z,ZHAO Q Y,et al.Erythrocyte-mimicking subcutaneous platform with a laser-controlled treatment against diabetes[J].J Control Release,2022,341:261-271.
[38] SEKHON U D S,SWINGLE K,GIRISH A,et al.Platelet-mimicking procoagulant nanoparticles augment hemostasis in animal models of bleeding[J].Sci Transl Med,2022,14(629):eabb8975.
[39] YANG L P,ZHAO P,WU Y J,et al.Treatment outcome and efficacy of therapeutic plasma exchange for transplant-associated thrombotic microangiopathy in a large real-world cohort study[J].Bone Marrow Transplant,2022,57(4):554-561.
[40] DEVECI B,SABA R,ALTUNAY H,et al.Severe acute hemolytic transfusion reaction treated with ruxolitinib and plasma exchange[J].Transfus Med Hemother,2021,48(4):250-253.
[41] OLMOS CALVO I,KUTEN-PELLA O,KRAMER K,et al.Optimization of lyophilized hyperacute serum (HAS) as a regenerative therapeutic in osteoarthritis[J].Int J Mol Sci,2021,22(14):7496.
[42] METHEETRAIRUT C,NGOWYUTAGON P,TUNGANU
NTARAT A,et al.Comparison of epitheliotrophic factors in platelet-rich plasma versus autologous serum and their treatment efficacy in dry eye disease[J].Sci Rep,2022,12(1):8906.
[43] QU Q,ZHOU Y,SHI P L,et al.Platelet-rich plasma for androgenic alopecia:a randomized,placebo-controlled,double-blind study and combined mice model experiment[J].J Cosmet Dermatol,2021,20(10):3227-3235.
[44] AFLATOONIAN A,LOTFI M,SAEED L,et al.Effects of intraovarian injection of autologous platelet-rich plasma on ovarian rejuvenation in poor responders and women with primary ovarian insufficiency[J].Reprod Sci,2021,28(7):2050-2059.
[45] IKEDA T,TERADA R,NAGURA Y,et al.High-dose intravenous iron supplementation after preoperative autologous blood donation is useful to prevent post-donation/preoperative anemia[J].Transfus Apher Sci,2022,61(3):103348.
[46] LIN Y X,YU S F,WU X F,et al.Clinical analysis of the therapeutic effect of plasma exchange on hypertriglyceridemic acute pancreatitis:a retrospective study[J].Transfusion,2022,62(1):72-81.
[47] KWIATKOWSKI J L,HAMDY M,EL-BESHLAWY A,et al.Deferiprone vs deferoxamine for transfusional iron overload in SCD and other anemias:a randomized,open-label noninferiority study[J].Blood Adv,2022,6(4):1243-1254.
[48] WU S S,CHEN Q,PAN J Y,et al.Platelet transfusion and mortality in patients with sepsis-induced thrombocytopenia:a propensity score matching analysis[J].Vox Sang,2022,117(10):1187-1194.
[49] ZHAO H Q,SERRANO K,CULIBRK B,et al.Cold-stored platelets are effective in an in vitro model of massive transfusion protocol assessed by rotational thromboelastometry[J].Transfusion,2022,62(Suppl 1):S53-S62.
[50] ZHANG Y W,FU X J,XIE X,et al.A novel model forecasting perioperative red blood cell transfusion[J].Sci Rep,2022,12(1):16127.
[51] ZHAO J C,SJÖLANDER A,EDGREN G.Mortality among patients undergoing blood transfusion in relation to donor sex and parity:a natural experiment[J].JAMA Intern Med,2022,182(7):747-756.
[52] TIAN X,KONG Y J,WANG J,et al.Development of the Chinese Haemovigilance Network and reporting of adverse transfusion reactions from 2018 to 2020[J].Vox Sang,2022,117(8):1027-1034.

2021—2022年度输血医学研究进展^*

Research Advances in Transfusion Medicine 2021-2022

RichHTML

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

关于本刊

作者中心

在线期刊

访问统计

联系我们

[1]	黄蓉, 张宁洁, 郝珂, 郭天虹, 黄雪原, 谷兰, 傅云峰, 黄远帅, 王勇军, 陈秉宇, 周岚, 桂嵘. 从《AABB技术手册》（18版-20版）看国际输血技术新走向^*[J]. 临床输血与检验, 2023, 25(2): 170-179.
[2]	邓桂花, 龙馨妍, 孙亚纯, 王雷萍, 张传国, 孟庆宝. 智慧型输血医学科的建设[J]. 临床输血与检验, 2023, 25(2): 185-189.
[3]	胡兴斌. 我国当前医学教育模式下输血医学研究生培养的思考与实践[J]. 临床输血与检验, 2022, 24(5): 554-559.
[4]	刘峰, 周吉成, 刘榕孜, 谭彬宾, 谢春梅. 国内部分高等医药院校开设输血医学课程的现状分析及建议[J]. 临床输血与检验, 2022, 24(4): 501-506.
[5]	黄柏勇, 李翠, 曹桂花, 金凤钟, 宁晓暄. 红细胞分布宽度（RDW）在器官衰竭中的临床研究进展[J]. 临床输血与检验, 2022, 24(2): 268-272.
[6]	于洋. 基于中国输血大讲堂的网络在线继续教育模式探索与实践[J]. 临床输血与检验, 2022, 24(1): 104-108.
[7]	陈学军, 王梦雅, 唐雀美, 沈月芳. 新生儿高胆红素血症换血治疗的现状及研究进展[J]. 临床输血与检验, 2021, 23(6): 696-699.
[8]	邵从军. 红细胞分布宽度在临床疾病诊疗中的研究进展[J]. 临床输血与检验, 2021, 23(3): 400-404.
[9]	于雪荞, 沈瀚, 曹小利. 细菌Ⅳ型分泌系统的研究进展^*[J]. 临床输血与检验, 2021, 23(2): 255-259.
[10]	吴建君, 史荣辉, 赵树铭. 临床输血医师工作内容探讨[J]. 临床输血与检验, 2021, 23(1): 17-19.
[11]	崔颖, 陈扬, 王文婷, 魏华, 穆士杰. PBL结合LBL教学模式在临床输血实习带教中的应用与体会[J]. 临床输血与检验, 2020, 22(1): 36-38.
[12]	吴雪萍, 杨文勇, 陆兴热, 高仕萍, 王孝梅. 输血科实习生带教体系的建立与应用研究[J]. 临床输血与检验, 2019, 21(5): 544-547.
[13]	赵丽坤, 卓海龙, 邵春, 燕骆群. 血液运输方式研究进展[J]. 临床输血与检验, 2019, 21(3): 333-336.
[14]	杨惠颖,任爱民,郑静,邱艳. 采供血机构建设高等医学院校临床教学基地的实践经验^*[J]. 临床输血与检验, 2017, 19(2): 190-193.
[15]	邱艳, 刘江. 标杆管理在输血医学管理中的应用^*[J]. 临床输血与检验, 2017, 19(1): 1-4.