单采血小板细菌污染致输血不良反应的病例统计分析

doi:10.3969/j.issn.1671-2587.2025.01.008

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (1): 59-63.DOI: 10.3969/j.issn.1671-2587.2025.01.008

单采血小板细菌污染致输血不良反应的病例统计分析

罗圆圆, 张晓娟, 马春娅, 付丽辉, 王泽珊, 于洋

中国人民解放军总医院第一医学中心输血医学科,北京 100853

收稿日期:2024-11-29 发布日期:2025-02-25
通讯作者: 于洋,主要从事临床输血学研究,（E-mail）yuyangpla301@163.com。
作者简介:罗圆圆,主要从事血型参比及血液安全监测相关研究,（E-mail）luo_yuan1987@163.com。并列第一作者：张晓娟,主要从事献血招募及血液安全监测相关研究,（E-mail）zhangxiaoj0926@163.com。

Statistical Analysis of Adverse Reaction Cases Caused by Bacterial Contamination with Apheresis Platelets Transfusion

LUO Yuanyuan, ZHANG Xiaojuan, MA Chunya, FU Lihui, WANG Zeshan, YU Yang

Department of Transfusion Medicine, The First Medical Center of PLA General Hospital, Beijing 100853

Received:2024-11-29 Published:2025-02-25

摘要/Abstract

摘要： 目的辨别输血传播细菌感染类输血反应,提高临床诊断率。方法对2021─2023年我院因血小板细菌污染导致的输血不良反应病例进行回顾性分析,归纳不同患者的输血不良反应症状及检测指标,了解其个体差异。结果共统计11例输血传播细菌感染的输血反应,其中男性6例,女性5例,多数为血液病患者,表现为体温升高,严重的输血反应出现持续的高热。不同患者表现的症状、体征有所差异,鉴别时容易和其他输血反应相混淆。由于病种及输血前用药情况,白系细胞输血反应前后无明显差异,血小板计数在输血反应后有所上升但未达到有效输注标准。输血反应后的C反应蛋白均值约为输血反应前的2倍,P>0.05,差异无统计学意义。输血反应后降钙素原和白介素-6检测的均值高于正常值百倍。输血反应发生后的体温明显升高,差异有统计学意义,P<0.05。结论单采血小板相关的输血传播细菌感染的临床症状差异较大,发热为主要表现,鉴别相对困难,相关感染指标可作为辅助诊断。

关键词: 输血传播细菌感染, 单采血小板, 细菌污染, 输血不良反应

Abstract: Objective To identify transfusion reactions caused by bacterial infections and improve the clinical diagnosis rate. Methods A retrospective analysis of transfusion reactions caused by bacterial contamination of platelet in our hospital from 2021 to 2023 was conducted to summarize the symptoms of transfusion adverse reactions in different patients and learn about their individual differences. Results A total of 11 cases of blood transfusion transmitted bacterial infections, including 6 males and 5 females, most of whom were hematological patients, showed elevated body temperature and persistent high fever in severe blood transfusion reactions. Different patients show different symptoms and signs, and it is easy to be confused with other transfusion reactions. Due to the disease type and pre-transfusion medication, there was no significant difference between leukocyte cells before and after transfusion reaction, and the platelet count increased after transfusion reaction but did not meet the effective transfusion standard. The mean C reactive protein after transfusion reaction was about 2 times that of before transfusion reaction, P>0.05, without statistically significant difference. The mean values of procalcitonin and interleukin-6 tests were 100 times higher than normal. Body temperature increased significantly after the transfusion reaction, with statistically significant differences, P<0.05. Conclusions The clinical symptoms of apheresis platelet-related transfusion-transmitted bacterial infection vary greatly, fever is the main manifestation, the differentiation is relatively difficult, and the relevant infection index can be used as auxiliary diagnosis.

Key words: Transfusion-transmitted bacterial infection, Platelet apheresis, Bacterial contamination, Adverse reactions to blood transfusion

中图分类号:

R457.1⁺3

罗圆圆, 张晓娟, 马春娅, 付丽辉, 王泽珊, 于洋. 单采血小板细菌污染致输血不良反应的病例统计分析[J]. 临床输血与检验, 2025, 27(1): 59-63.

LUO Yuanyuan, ZHANG Xiaojuan, MA Chunya, FU Lihui, WANG Zeshan, YU Yang. Statistical Analysis of Adverse Reaction Cases Caused by Bacterial Contamination with Apheresis Platelets Transfusion[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(1): 59-63.

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单采血小板细菌污染致输血不良反应的病例统计分析

Statistical Analysis of Adverse Reaction Cases Caused by Bacterial Contamination with Apheresis Platelets Transfusion

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