成分献血与骨代谢及骨密度相关性研究进展*

doi:10.3969/j.issn.1671-2587.2023.01.024

临床输血与检验 ›› 2023, Vol. 25 ›› Issue (1): 143-148.DOI: 10.3969/j.issn.1671-2587.2023.01.024

• 综述 • 上一篇

成分献血与骨代谢及骨密度相关性研究进展^*

李婉, 王娅, 肖光林, 陈勇军

610052 成都中国医学科学院北京协和医学院输血研究所

收稿日期:2022-11-07 发布日期:2023-02-20
通讯作者: 王娅,女,副研究员,硕士,主要从事献血献浆者健康安全研究,（E-mail）175235831@qq.com。
作者简介:李婉（1999-）,女,硕士在读,主要从事输血医学方面研究,（E-mail）2971317731@qq.com。
基金资助:
*本课题受中国医学科学院医学与健康科技创新工程重大协同创新项目（No.2021-I2M-1-060）资助

Research Progress in the Relationship of Apheresis Donation to Bone Metabolism and Bone Mineral Density

LI Wan, WANG Ya, XIAO Guang-lin, et al

Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu 610052

Received:2022-11-07 Published:2023-02-20

摘要/Abstract

摘要： 成分献血是临床用血及血液制品原料的重要来源。长期成分献血导致的电解质水平变化和血液成分丢失,均与骨密度及骨代谢存在相关性。因此成分献血作为一种献血方式是否对骨代谢和骨密度造成影响已引起越来越多的关注。本文从钙平衡、铁代谢、脂代谢这三个方面总结并探讨成分献血与骨代谢及骨密度的相关性及潜在可能机制,以期为保障成分献血者健康安全提供依据。

关键词: 成分献血, 单采血浆, 单采血小板, 骨密度, 骨质疏松症

Abstract: Apheresis donation is an important source of clinical blood and raw materials for blood products. Changes in electrolyte levels and loss of blood components caused by long-term apheresis donation are related to bone density and bone metabolism. Therefore, there is growing concern about whether apheresis donation as a mode of behavior has any impact on bone metabolism and bone density. In this paper, the correlation of apheresis donation with bone metabolism and bone density as well as the potential mechanisms are summarized and discussed from the three aspects of calcium balance, iron metabolism and lipid metabolism, in order to provide a basis for ensuring the health and safety of component blood donors.

Key words: Apheresis donation, Plasmapheresis, Plateletpheresis, Bone mineral density osteoporosis

中图分类号:

R457

李婉, 王娅, 肖光林, 陈勇军. 成分献血与骨代谢及骨密度相关性研究进展^*[J]. 临床输血与检验, 2023, 25(1): 143-148.

LI Wan, WANG Ya, XIAO Guang-lin, et al. Research Progress in the Relationship of Apheresis Donation to Bone Metabolism and Bone Mineral Density[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(1): 143-148.

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成分献血与骨代谢及骨密度相关性研究进展^*

Research Progress in the Relationship of Apheresis Donation to Bone Metabolism and Bone Mineral Density

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