间隔14~16天多次单采血小板献血者血液生化指标变化的研究*

doi:10.3969/j.issn.1671-2587.2021.05.022

临床输血与检验 ›› 2021, Vol. 23 ›› Issue (5): 652-654.DOI: 10.3969/j.issn.1671-2587.2021.05.022

间隔14~16天多次单采血小板献血者血液生化指标变化的研究^*

廖红梅, 毛伟, 向宇培, 李军

400015 重庆市血液中心（廖红梅,毛伟,李军）; 重庆市九龙坡区人民医院（向宇培）

收稿日期:2020-10-14 发布日期:2021-10-20
通讯作者: 李军,男,重庆人,主治医师,硕士,主要从事单采血小板采集相关研究,（E-mail）42014452@qq.com。
作者简介:廖红梅(1985-),女,重庆人,主管检验师,本科,主要从事血液检测和献血者健康的研究,（E-mail）619679610@qq.com。
基金资助:
*本课题受重庆市渝中区科学技术委员会项目（No.20140130）资助

Study on the Changes of Blood Biochemical Indicators in Frequent Plateletpheresis Donors with an Interval of 14~16 Days

LIAO Hong-mei, MAO Wei, XIANG Yu-pei, et al

Chongqing Blood Center 400015

Received:2020-10-14 Published:2021-10-20

摘要/Abstract

摘要： 目的研究捐献20次且间隔14~16天的单采血小板献血者血液生化指标的变化,为单采血小板献血者的招募和管理策略提供依据。方法以多次单采血小板献血者作为研究对象。共42例,均为男性,年龄25~54岁,捐献间隔时间为14~16天。分为三组：第1次捐献前留取的血液标本作为对照组,第10次和第20次作为观察组1和观察组2。生化检测项目包括：ALT、Alb、TP、Ca、P、Fe和SF。结果观察组1与观察组2样本ALT、Alb、TP、Ca、P和Fe检测结果和对照组相比,差异无统计学意义（P>0.05）。但是,观察组1和观察组2样本SF水平与对照组相比,差异具有统计学意义（P<0.05）。结论连续20次且间隔14~16天单采血小板的男性献血者外周血ALT、ALB、TP、Ca、P和Fe无明显变化,但捐献10次以上存在铁存储下降的风险。

关键词: 单采血小板, 生化, 献血者

Abstract: Objective To provide a basis for the recruitment and management strategies of donors, we tested whether there were the biochemical changes of blood in donors who plateletpheresis 20 consecutive times and with an interval of 14~16 days, and evaluated the impact of shortening the donation interval. Methods The test results of blood samples taken from donors before plateletpheresis were used as subjects. A total of 42 male cases, aged 25~54, and with an interval of 14~16 days. They were divided into three groups: the test results of the blood samples taken before the first plateletpheresis were used as the control group, and the 10th and 20th test results were used as the observation group 1 and the observation group 2. Blood biochemical tests include: ALT, Alb, TP, Ca, P, Fe and SF. Results Compared with the control group, there was no significant difference in the ALT, Alb, TP, Ca, P and Fe detection results of blood donors between observation group 1 and group 2 (P>0.05). However, there was a statistically significant difference in the SF test results of blood donors among observation group 1 and group 2 and the control group (P<0.05). Conclusion There was no significant change in ALT, Alb, TP, Ca, P, and Fe in male donors who plateletpheresis 20 consecutive times and with an interval of 14~16 days, but the SF would decrease if more than consecutive 10 times.

Key words: Plateletpheresis, Blood biochemical, Blood donors

中图分类号:

R457.1

廖红梅, 毛伟, 向宇培, 李军. 间隔14~16天多次单采血小板献血者血液生化指标变化的研究^*[J]. 临床输血与检验, 2021, 23(5): 652-654.

LIAO Hong-mei, MAO Wei, XIANG Yu-pei, et al. Study on the Changes of Blood Biochemical Indicators in Frequent Plateletpheresis Donors with an Interval of 14~16 Days[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2021, 23(5): 652-654.

参考文献

[1] J L T,R J T,P B,et al.Plateletpheresis in a disposable system.[J].Vox sanguinis,1971,20(5).
[2] BARBOSA M H,SILVA K F N D,COELHO D Q,et al. Risk factors associated with the occurrence of adverse events in plateletpheresis donation[J].Revista Brasileira De Hematologia E Hemoterapia,2014,36(3):191-195.
[3] ALI A M,MCAVOY A T,ALI M A M,et al.An approach to determine objectively minimum hemoglobin standards for blood donors[J]. Transfusion,1985,25(3):286-288.
[4] LI J,LIAO H.Effects of frequent multiple plateletpheresis on complete blood count values of blood donors[J].Asia-Pacific Journal of Blood Types and Genes,2018,2(4):255-258.
[5] THOKALA R P,RADHAKRISHNAN K,ANANDAN A,et al.Recovery of Platelet Count among Apheresis Platelet Donors[J].J Clin Diagn Res,2016,10(12):C1-C4.
[6] LOVE E,PENDRY K,HUNT L.Analysis of pre- and post-donation haematological values in plateletpheresis donors.[J].Vox Sanguinis,2015,12(2):123-125.
[7] KATZ L,PALMER K,MCDONNELL E,et al.Frequent plateletpheresis does not clinically significantly decrease platelet counts in donors[J].Transfusion,2010,47(9):1601-1606.
[8] BECHTLOFF S,TRAN-MY B,HAUBELT H,et al.A prospective trial on the safety of long-term intensive plasmapheresis in donors[J].Vox Sanguinis,2010,88(3):189-195.
[9] GRAU K,VASAN S K,ROSTGAARD K,et al.No association between frequent apheresis donation and risk of fractures:a retrospective cohort analysis from Sweden[J].Transfusion,2017,57(2):390-396.
[10] ERIN M L,MARY C,INES E,et al.Worldwide prevalence of anaemia,WHO Vitamin and Mineral Nutrition Information System,1993-2005[J].Public Health Nutrition,2009,12(4):444-454.
[11] HENTZE M W,MUCKENTHALER M U,GALY B,et al.Two to Tango:Regulation of Mammalian Iron Metabolism[J].Cell,2010,142(1):24-38.
[12] HEUFT H G,MOOG R,FISCHER E G,et al.Donor safety in triple plateletpheresis:results from the German and Austrian Plateletpheresis Study Group multicenter trial[J].Transfusion,2013,53(1):211-220.
[13] WANG W,COFFMAN LGTORTI S V.Serum ferritin:Past,present and future[J].BBA-General Subjects,2010,1800(8):760-769.
[14] GORLIN J,KATZ L,ELSMORE D,et al.Prevalence of blood donor iron deficiency and feasibility ferritin-based iron replacement:a blood collection agency-based study[J].Vox Sanguinis,2016,111(2):206-208.

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间隔14~16天多次单采血小板献血者血液生化指标变化的研究^*

Study on the Changes of Blood Biochemical Indicators in Frequent Plateletpheresis Donors with an Interval of 14~16 Days

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